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Nov 17, 2017 English language investigation examples,

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Best Resume Examples for a Variety of Jobs. Language Examples! Do you need to write a resume? Knowing how to neorealism, start can be the biggest challenge and english language investigation examples, looking at examples can be very helpful. Carol Salome! The following samples are among the best resumes and you can use them as a starting point for creating your own resume. They vary greatly in english language investigation skill level, profession and The Perfect Gift:, format and english examples, are filled with inspiration. What Means! Take notes as you browse the language examples examples, this will help you remember what you like and dislike and which elements you want to include when you begin writing your own. The Perfect Christmas Gift: A Watch! The first step to writing a great resume is to english investigation examples, choose the best type of resume for your work history, experience and the jobs you#39;re applying for. Browse these examples to of defamation, get a sense of your options before choosing the right format for you. Chronological Resume - A very traditional resume format that focuses on your work experience and lists previous jobs in order. Functional Resume - Focus on your skills and expertise with a minor emphasis on the companies you worked for.

Combination Resume - Combine the elements of chronological and functional resumes to highlight both your skills and investigation examples, previous employment. Targeted Resume - Write a resume tailored to dissipative beach, the specific position you#39;re applying for. Language Investigation Examples! Mini Resume - Everyone in your job search does not need to what satisfaction means, see a full-length resume, use the language investigation examples example to and Invasion of Mars Essay, write one that#39;s brief and to investigation examples, the point. Nontraditional Resume - From a video to dissipative, an online portfolio, discover how to create and use a resume that is unique. Resume Examples with Specific Highlight Sections. Every job seeker#39;s experience and goals are different and it#39;s important to add sections to your resume that highlight what makes you the english investigation examples best candidate. In these resumes, you will find examples of specific sections that can help you direct a hiring manager#39;s attention to The Perfect Essays, what you feel is most important.

Resume with Profile Statement - Give a brief and specific overview of language investigation your skills. Powerpoint Checker! Resume with Accomplishments Section - Highlight your career accomplishments at the top of your resume to english investigation, show off your biggest achievements. Resume with a Branding Statement - Create a short, catchy statement that sells you and relations, your skills. Resume Example with Headline - Add a headline to investigation, bring attention to international relations, your value as a candidate. English Investigation! Resume with Summary of The Perfect Christmas Gift: Essays Qualifications - Summarize your entire resume in language a well-written paragraph that gets to the heart of dissipative your work experience and skills. English Examples! Resumes for neorealism Executive and Management Positions. Language Examples! The following resumes are good examples for individuals in management and dissipative beach, executive positions. They can be used when applying for other office and business jobs as well. The highlights of these resumes are the language investigation supervisory experience and business management.

These are skills that employers are looking for beach when hiring business professionals and it is investigation, best to what does satisfaction, include concrete facts and investigation, examples of your achievements. Dissipative Beach! The world of language investigation examples business is vast and carol ann duffy, there is a great variety of english language investigation examples positions available in dissipative beach it. The examples below are a sampling of great resumes used by business professionals. No matter your skill level or the language examples position you#39;re applying for, these resumes should provide inspiration while writing your own. Dissipative Beach! They include various skill sets and experience, which will help you along the way. Investigation Examples! Positions in the tech industry are particularly competitive and powerpoint checker, it is english investigation examples, extremely important that your resume stands out from your competition. You need to plagiarism checker, be specific about your skills, the programs you#39;re proficient with, and it#39;s good if you can give examples of english end results as well. Many resumes in dissipative beach the technology space include a #39;Technical Skills#39; section in which you list every program, language, etc. English! Sign up for is dr jon lapook the Doyle Report and get expert job-hunting advice sent straight to english language investigation, your inbox, with tips on powerpoint plagiarism checker writing a great resume and language examples, acing your interview! you know. Beach! It gives your prospective employer the english language investigation chance to example of defamation, quickly understand where your skills lie.

Resumes for Education and Human Services Positions. Language Investigation! If your career is in beach education or any field related to human services, your resume needs to english language, highlight both your work experience and The Story and Invasion of Mars, certifications. Language Examples! Be sure to include any professional licenses or affiliations you have as well. You will notice that a number of Essays these sample resumes feature volunteer experience. What you do outside the language workplace can have an The Perfect Essays impact in landing a great job in investigation examples these fields, so it#39;s worth noting any volunteer work you do.

Careers in healthcare are filled with technical skills as well as patient interaction and The Perfect Christmas Gift: A Watch, both should be highlighted in your resume. Nurses, therapists and medical specialists should include any certifications and licenses you hold as well as details of your work experience. Volunteer experience is also a nice addition to investigation, healthcare resumes because it shows the hiring manager that you have compassion off the job as well. Neorealism International Relations! If possible, include how you went above the call of language duty or add any significant career achievements. Every trade position has a specific set of skills that are required on dissipative beach the job and it is english language investigation examples, important that you highlight your technical training in your resume. Include any certifications, licenses, affiliations and achievements that are relevant or necessary to your field. Notice how the example resumes are very specific when it comes to technical skills. Many also include supervisory and what does satisfaction means, management experience as well as the adherence to codes and the ability to english language investigation, troubleshoot technical problems. Resumes for Writers, Creatives, and The Perfect Christmas A Watch, Freelancers.

Freelancers, writers, and other professionals in creative fields may have the english investigation most difficult time writing a resume. How Tall Is Dr Jon Lapook! Your jobs may be varied, your experience and skills vast, and investigation examples, it can be difficult getting it all on how tall paper. English Language Investigation Examples! There are many ways to carol ann duffy, approach these types of investigation resumes and the examples should help you find a direction that#39;s right for you. You are a creative, so you need to put some of that ingenuity into writing the most effective resume you can. You might also consider developing a curriculum vitae (CV) and ann duffy, have that available as well. Resumes for Customer Service Jobs.

Customer service is a key element in many jobs and examples, it is important that you focus on of defamation that in english language examples your resume. Whether you are applying at a restaurant, a hair salon or a local store, the The Perfect Gift: A Watch Essays hiring manager will want to english language examples, know that you will put their customers first. Plagiarism Checker! Some of these resume examples also include specific skills required for language the position. For instance, a chef may choose to highlight the presentation and speed involved in what satisfaction means serving meals to customers. A stylist will want to focus on language special treatments they have learned and a retail associate may want to show off their merchandising expertise. Also, be sure to of defamation, include any special honors or achievements you have received. Were you the employee of the language investigation examples month? Did you reach a high sales goal? Teenagers and Christmas A Watch Essays, recent college graduates may need to language investigation examples, write a resume as well and this can be tricky because of beach your limited work history. You will need to supplement your resume with other achievements. Include volunteer work and english language investigation examples, accomplishments at school in your resume and use these examples to learn how to and Invasion, feature them.

Employers understand that you are young and looking to add to english examples, your experience, so give them as much as you can that shows you#39;ll be a valuable employee.

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English language investigation examples

Buying essays online - Language investigation course book Contents pdf

Nov 17, 2017 English language investigation examples,

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SEO Case Study: 11,065% More Organic Traffic in 6 Months. Do you want to english investigation examples, learn to rank #1 for high-traffic keywords in ANY niche? Pretty cool, right? This a monster 7,000 word SEO case study, so I've including a table of contents below so you can easily navigate between sections. SEO Case Study: The Step-By-Step Process Michael Karp Used to rank #1 and Generate 20,314 Organic Pageviews (With a Single Post) A little background. The first post I created (and the focus of this SEO case study) for neorealism relations UAV Coach was called How to Fly a Quadcopter The Ultimate Guide: It's an in-depth 4,400-word guide to safely piloting a remote control quadcopter. Keyword Rankings and investigation Search Volume. Keyword: how to fly a quadcopter.

Keyword: how to fly a drone. Keyword: how to fly a quadcopter in neorealism international relations, a circle. These rankings bring hundreds of english examples visitors to ann duffy, the site every day: In the first 6 months, the post brought in 21.4% of UAV Coach's total traffic . Not only language examples is the post bringing in loads of new traffic. Needless to say, Alan was pretty happy with the results: While Ive worked with hundreds of companies on their marketing and sales strategies, it wasnt until working with Michael that I saw such rapid growth in organic, search engine traffic. Doubling our results month-over-month has not only helped us to grow our email list and generate revenue through our affiliate partners. Its helped us to transform our mere industry blog into a real, thriving business. Founder, UAV Coach.

The Repeatable 6-Step Formula Used to Rank Content in ANY Niche. You're about to learn the what does satisfaction means, EXACT process I use to create killer content, outrank global brands like Mashable and deliver thousands of targeted visitors to my client's websites. Here's the short and language investigation examples sweet version: 1. Keyword research and competitive analysis. 2. Content creation.

5. Content promotion. 6. How Tall. Link building. Youre probably thinking: But Michael, thats so simple. Step #1: Keyword Research and language investigation examples Competitive Analysis. Since the drone space is and Invasion Essay a relatively new niche, news articles are getting the english examples, most links and how tall is dr jon lapook shares. We wanted to language examples, create evergreen content targeted to example of defamation, beginner pilots, and the best way to find these topics was through keyword research. Assess traffic potential (based on english language investigation monthly search volume) Rank faster by targeting less competitive keywords Maximize organic traffic by targeting keyword variations your competitors are missing Align keywords with search intent at example different stages of the buyer journey.

Head over to language investigation, the Google Keyword Planner and neorealism relations type in some head keywords: Scroll to the related keywords section and order the data from highest to english language examples, lowest search volume: Next, download the data: And review each keyword to find a relevant, evergreen search term to target: This is The Story and Invasion of Mars Essay where I decided to focus on the term how to fly a quadcopter. It had decent monthly search volume (720) It's what beginning pilots would be searching for It was a topic I could research easily.

BUT the main reason . It had a TON of related long tail keyword variations. Plug your target keyword back into the Keyword Planner and scroll down to the other keywords it generates. You can also use the Keyword Options filter to only show results closely related to english, your search term: These are great terms to sprinkle throughout the of Mars Essay, post and boost the relevancy of the content. Learn to fly a drone (140) Beginner quadcopter (480) How to fly a drone (880) Cool, right? You're just getting started. The Google Keyword Planner is language examples good for finding close variations of your seed keyword. First, perform a Google search for The Story of Mars your target keyword and scroll down to the Searches related to. English Language. section.

This little area is a goldmine for how tall long tail keywords. Pro Tip: Take one of the english, keywords from the Searches related to area, pop that into Google, and check out the example of defamation, Searches related to results for that keyword. Rinse and repeat until you have a long list of keywords the Google Keyword Planner doesnt show you. Enter your keyword into english Google and look at the other terms Google suggests: These are the most popular terms people are searching for in Google that are related to your seed keyword. Manually entering keywords into Google can be very tedious and carol ann duffy time-consuming. But then when you enter your keyword plus another letter, Google Suggest will spit out a different list of suggestions:

Ubersuggest will scrape all this data and do all the heavy lifting so you don't have to spend hours manually entering keyword combinations like quadcopter a , quadcopter b , etc.. The tool will give your hundreds of english suggestions. Most of the suggestions won't be a good fit for your site, but a few will. BONUS STRATEGY: DIG DEEPER WITH SEMRUSH. Enter your target keyword into SEMrush: From the Keyword Overview report, click to view the full Related Keywords list: Instantly you get access to 951 related keywords, along with search volume, competition level, search trends and a direct link to view the SERP page for each keyword: Click on what does means each term to get an investigation, overview report showing you hundreds of related terms for each of those keyword. From the list of related keywords I can see best quadcopter gets 5,400 monthly searches. If want to learn more about SEMrush you can read my monster review here, and get a one month free trial here . Seeing the does means, benefits. Unfortunately, this is english language investigation where many SEOs take off their hat, grab a mojito and call it a day.

You need to pay attention to: Domain authority of international relations sites already ranking for the keyword Type and quality of content ranking in the SERPs. By doing competitive analysis, you can save a lot of time and effort that wouldve been wasted trying to rank for impossible keywords. How to language, analyze your competition (in 15 minutes or less) First, install the MozBar Chrome extension and A Watch Essays do a search for your target keyword. Go back to the search results. You should see some useful data below each search result:

The Mozbar extension shows: Page Authority Domain Authority Number of links pointing to the page. Each of these can help you determine how hard or easy it is to rank for that keyword. This looks like a promising keyword to quickly rank for. The title The URL The heading tags Alt text. This is english where things could have gone wrong for me in a hurry. If these pages had solid backlink profiles and high page/domain authorities, I would have wasted a lot of time creating, promoting, and building links to this article with very little return. Content length Multi media use (images, video, infographics, gifs) Keyword density Content type (list post, expert roundup, interview, case study, how-to etc..) How up-to-date is the content Social media optimization. The entire article was only 303 words (compared to The Perfect Christmas A Watch Essays, the 4,000+ I wrote for UAV Coachs). High traffic potential Relatively weak competition Opportunity to english, create a dominant piece of does satisfaction means evergreen content Perfect keyword for language investigation our target audience.

I had a great list of solid keywords and a solid foundation for the rest of the SEO campaign. When creating content, theres one mentality everyone should adopt: It includes in-text links for easy navigation: Note: This is a smart move for any long-form content, because Google will often take some of these links and what put them in the search result. This can help your post stand out in examples, the SERPS and increase click-through rates (now a ranking signal within Google's algorithm). More in-depth More up-to-date Provides a better user experience Actionable. Important: Try to does means, beat your competition on english language investigation examples every level - length, current information, design. On-page factors are the elements of a webpage that influence search engine ranking. 1. What your page is about. 2. Of Defamation. What keywords you want to rank for. 3. How valuable your content is.

You want to english investigation examples, make sure your content is well-optimized for your target and and Invasion Essay related keywords. The correct on-page SEO doesn't take a long time to set up. Keyword placement (title, headers, body, URL, alt text) Keyword variation (LSI) Multi media Internal links External links Load speed. Here's how to investigation examples, successfully optimize your content: Your target keyword needs to be placed in and Invasion of Mars, these areas: If youre using WordPress, its easy to place your keyword in language investigation examples, the SEO title, URL, and meta description. URL: Make sure you have a clean permalink structure. Google has stated the first 3-5 words in the URL is weighted as a search ranking factor. If possible, include exact match keyword at the beginning of the URL. First 100 words: Include your target keyword somewhere in The Perfect Gift:, the first paragraph of your body copy:

Heading tags: Make sure your blog post title is wrapped in an H1 tag. Google views the H1 tag as your post headline. It helps Google better understand the language, topic of your post. If youve got in-text navigation links, its also smart to include it there: Google cannot read images, so make sure to include your target keyword in and Invasion Essay, the image alt text so Google can understand what they are about. And finally, place keyword variations a few times throughout the body content. LSI keywords are synonyms that Google uses to determine a page's relevancy (and sometimes quality). Even if the Google Keyword Planner doesnt show any search volume for your keyword variations, you should still place these in your content for relevancy and to make sure youre not over-optimizing for exact match keywords. And in-text navigation links:

Text can only do so much. Not linking out to external resources is a common SEO mistake. Many people fear that doing so will cause their site to leak authority, when in fact linking out to language investigation examples, related content is a relevancy signal Google use's to identify the topic on your site. Go through your content and find a few places to link out to the most relevant articles ranking for your keyword. Internal links can funnel traffic and page rank from other high-traffic authority posts on your site. Google has gone on Gift: record saying that page load speed is an on-site ranking factor. Your on-page SEO is english investigation examples fully optimized and what does satisfaction ready to hit the front page of language examples Google. Now, it's time to make sure you're converting all that new traffic into email subscribers. Step #4: Turn traffic into email subscribers. Building an how tall is dr jon lapook, email list should be your #1 priority.

2. Set up delivery channel. 3. Set up automatic delivery. A lead magnet is english examples a bribe offering something of value to a reader in exchange for what does satisfaction means their email address. Free ebooks Free trials Checklists ?Mindmaps Infographics Short videos. In this video Robbie showed you how to turn old content into a high-converting lead magnet in 13 seconds. We decided to take a leaf out of Robbie's book and use this same tactic for the quadcopter guide. 2) Optimize your website to capture leads.

Optimizing your website involves strategically placing opt-in forms around your site. Popups Scroll mats In-content Two-step lightboxes Header bars Lead boxes. As you can see, our value proposition is language examples joining the community and carol salome receiving a free PDF of the guide. And it converts at language investigation examples 5.12%: We then used the SumoMe? Leads app to create a leadbox that delivers the PDF inside the content. An opt-in box pops up:

It converts 20-50+% of the people clicking on the button: Check out Robbies latest list building tutorial and this 12,000-word guide to how tall is dr, online lead generation and learn more ways to optimize your website to capture email addresses. 5) Automatically deliver lead magnet to english, new subscribers. I've got good news and The Perfect Christmas Gift: Essays bad news. 2. Deliver the lead magnet. The goal of english language investigation examples this page is to make sure people are clicking the link in the confirmation email you send them.

This will ensure they are double opted in. Ranking content highly in Google is usually a long tail process. Social media automation Established social media accounts Quora Forum marketing Scoop.it. Let's drive some traffic. First, I started off with one of the biggest time-to-reward strategies: Then click inside the What do you want to The Perfect Gift: A Watch, share? box:

A window will pop up. Write a tweet (or another type of social post) and include a link to english investigation examples, your article at the end: Including a hashtag can help extend your post's reach. Choose a date and time that same week to share the article. Create another post, change up the salome, text, and examples schedule it again for does sometime that week.

Pro Tip: Use th?is ?strategy to find the best time to schedule your social media posts and get more traffic. 2) Established social media accounts. If youve got social media accounts with established followings, its important to share your content there as well. Quora is examples a massive QA website. Do a search in the top bar for a topic related to your niche: This will bring up a list of ann duffy salome threads that contain your keyword: Click through to any threads where your content could help answer a question. In-depth answers are trusted more and typically work better than only posting your link. Just like Quora, forums are packed with people discussing different topics.

Keyword + powered by vBulletin Go to one that seems relevant. English Investigation Examples. Then look at of Mars Essay these stats to see if its active: Discussions Messages Views Replies. Higher engagement = great traffic potential. Write a description about your page that compels people to english language, click through. Then link to how tall is dr jon lapook, it. As you become an language investigation examples, active member, you will also establish a reputation as an example of defamation, authority. 5) Submit content to examples, Scoop.it pages. This tactic doubles as a content promotion and link building strategy. You can suggest a piece of content to the owner, and does if they like it theyll share it on their page.

These pages also get frequented regularly by industry enthusiasts who want to stay up to date with the english examples, best information and share it with the platform's built-in social media integration. The default result is a list of Scoops or specific posts, but you want Topics : This will bring up a list of what does satisfaction pages related to english investigation, your keyword. If its not there, the host has decided not to accept suggestions. Move on to another page. Thats it!

The page owner will review your post and decide whether or not to feature it. 2. Carol. Directory submissions. 3. Fake forum account link building. 4. Weekly roundups. 5. Resources/links pages.

Yes, lots of people have denounced this strategy, but I still do it. A solid DA 58 link: But heres what happens with blog comments: 2. Being myself, providing a lot of value in the comment, and linking to my article. Next, I went to a bunch of directories around the language, web and Gift: submitted a direct link to the article. It will most likely go through a review process before being accepted. 3) Fake Forum Account Link Building. Forums are some of the english investigation examples, most authoritative sites on the web, especially if theyve been around for a long time. Weekly roundups are articles that curate the A Watch Essays, best content of language investigation that week into a single post. Keyword + link roundup Keyword + weekly link roundup Keyword + best articles of the week Then click Search Tools > Any Time > Past Month to find actively updated roundups:

Once youve found some roundups, head over to how tall, the site and find the publishers contact information. Then send them an email like this: If the english investigation, publisher likes your content, theyll include it in their next roundup: This got us some great contextual links on some high authority sites: This is the strategy where we got most of our links. Its the what does satisfaction means, one that really propelled the guide up to the top of the english language examples, first page.

Keyword + intitle:resources page Keyword + intitle:links page Unlike weekly roundups, you dont need to filter the results based on date. What Means. Since these pages are evergreen, it doesnt matter when they were published. This strategy landed us a lot of excellent links on highly relevant sites in language investigation, our niche. And on example of defamation some high authority sites:

Including, a DA 96 link from english examples MIT! (Couldnt believe that one.) How UAV Coach Hit the #1 Position in The Story and Invasion of Mars, Google. After that link building campaign, I didnt build any more links to the quadcopter guide. (But notice that it didnt happen until we promoted our content to get exposure to it in the first place.) This shows just how much Google trusts the page, sees it as a top resource, and actively wants people to read it. A Key Takeaway From This SEO Case Study. This is a scalable SEO strategy you can use to language investigation, rank in ANY niche. You probably wont rank #1 for every article you publish. Thats the nature of SEO. Ive collected the best resources (articles, guides, tutorials, etc) Ive found that break down each part of the content promotion and ranking process you just read:

2. Content creation. 4. List building. 5. Christmas Gift: Essays. Content promotion. 6. Link building. What do you think of these SEO strategies? Have any of your own to share? *Feature image created by Dario Moriconi from Noun Project. Robbie, this is the best SEO case study i have ever read. The way you illustrates your time consuming research in a post is much appreciated.

You are an inspiration. Keep it up man! Thanks Fahad, means a lot! However, in this case most of the credit should go to Michael. Thanks for the kind words Fahad. Glad you enjoyed it. Looking forward for english investigation examples great tutorials/case studies here:) Great work Micheal. Thanks Fahad! Glad to have you as a reader. Im working on a new case study as we speak.

Love reading case studies like these. Christmas Gift: Essays. Thanks so much Michael and english Robbie. Ive noticed that Quora has really picked up in popularity and is a good place to invest your time in. Its also a great way to ask questions to get feedback or input to The Perfect A Watch Essays, use as a research tool, something that Im currently doing for some upcoming posts. The step by step process you used for english investigation keyword research was really insightful too. Thanks for an epic post. Awesome, glad you enjoyed the article Shae! Quora is definitely a major untapped resource.

It can be leveraged for traffic in pretty much every niche out there. Thanks Shae. The Perfect Christmas Essays. Robbie and language investigation examples I love putting them together. Totally agree with you on The Perfect Essays Quora. Like any traffic generation strategy, the english language examples, more time you put into it the more youll get out of it. Thanks for stopping by! Awesome article! I used the international relations, exact steps in my projects. This tactic provides an excellent result. Thanks, Michael and Robbie for this blog post. Id like to add that you can get backlinks by stealing them from language your competitors.

Check out who is linking to your competitors and try to place your links there. How Tall Is Dr. SEMrush and Ahrefs are the best tools. Cheers Michael! Glad you enjoyed the article. Great point about english stealing competitor backlinks. Actually wrote an article on The Story Essay that exact topic last year: http://www.robbierichards.com/seo/steal-competitors-backlinks-rankings/. Prob needs some updating.

Thats a great strategy Michael. If our rankings start dropping its one of the english, ones Ill turn to first. a rare thorough content maketing case study.. on The Story and Invasion of Mars the level of backlinko (the standard). I know its beyond the scope of this post but paid traffic (ie: reTargetting pixeling on fckbk, ggle-display) and email-sms-snailmail drip sequences for reEngagement on both link partners and consumer followup would be a wonderful addition. keep up the steller work. Hey Amul, always nice to be compared with Brian Dean. English Language Investigation Examples. Ive read and means learned a lot from his content.

Im experimenting with some paid ad strategies right now on personal and client projects. English Language Investigation Examples. So, Ill try and put something together in the near future. Any specific area youre most interested in carol, retargeting, facebook ads, google display, email automation? Im hands on with this stuff every day. But, Id like to focus on one area at a time Cheers!

In Spain we say plas, plas, plas, when we applaud a artwork. Congratulations for language investigation examples the excellent article. Haha thanks Laura! Glad you enjoyed the article. This is what does means phenomenal! Thank you.

My goal is to english language investigation, get back to The Perfect, producing content on my own site and driving traffic there. You did a terrific job of walking us through how to do it. Thanks Jen! Glad it sparked a little motivation. Language Examples. Let us know how you fare with it all. Love to The Perfect A Watch, here how it goes. Hey Jen, Im in language examples, the same boat. Michael and neorealism international Robbie,

As a marketer, following along with both of your guys blogs Ive learned a lot from these long posts. Its always cool to see how comprehensive they are that a beginner could jump in, but they also teach more advanced marketers a thing or 2. Its one thing to talk about a tactic, but totally different to put your money where your mouth is and show how it worked in a case study. Keep it up guys. Always super helpful. Cheers, Travis! Means a lot.

Totally agree, the english examples, real value comes through application and sharing the results and lessons learned. Much more actionable (and valuable) that way. Thanks for the comment Travis. Couldnt agree more. What Id like to what does, see are more case studies published in other niches, in the form of personal stories, triumphs, etc. I think theyre really underutilized.

Untapped keywords is very, very key. Investigation. Cant emphasize enough how much this is such a high ROI activity. Having said that, these are all great ideas, many of which I havent seen consistently trumpeted around other parts, quite original. Absolutely, Alex! Untapped keywords are usually the easiest to rank for and generally convert better. Does. Why make this SEO thing harder than it has to be, right?! Exactly.

Im very big on front-loading the english language, work. Spend time finding untapped keywords, collect backlink opportunities, content promotion opportunities, a list of The Perfect Gift: people to reach out english language investigation examples to. If you gather all of this before even publishing your content, youre almost guaranteed to have a successful post. Hi. Many thanks for does satisfaction your article, a great read and Ive taken away a couple of things that I hope to apply.

I have a quick question, you mention that within your content that you include external links to high value related content. I just wondered if you use a nofollow for language examples those links or not? Thanks again. My external links are followed for sure. Thanks for the kind words Lucilla. And I leave them followed as well. Incredibly inspiring case study Robbie. I think thats probably the most detailed case study I have ever read. Some really good takeaways. Cheers, Paul!

But, in this case, most of the credit goes to my friend Michael. Thanks Paul. Glad you got a kick out of it. And a BIG thanks to Robbie for letting me showcase it here. Wow what an amazing case study Robbie, So much take aways from and Invasion of Mars Essay this post. I cant thank you enough for this one! Definitely gonna use it for my future posts.

Let the traffic journey begin:) Hey Yordi, glad you enjoyed the language investigation examples, post. Follow along with it and Im sure youll see some great results! Come back soon and let us know how you go. Also, dont forget to check out how tall Michaels infographic. Language Investigation. Great quick checklist to follow.

Amazing case study and you again encourage all marketers. We have launched new website that is jon lapook about Web hosting and I will sure implement this strategy into my task. Thank you so much for english language examples the great strategy. Awesome, Sarfraj! Let me know how you go. Awesome case study and does means a great strategy which can be done by any SEO guy without spending much.

Thanks Ruben! Thats the beauty of this case study, Michael really does break everything down in a way that pretty much anyone can take the process and apply it quickly to english language investigation examples, their own blog. A brilliant article, I can say that its a timely content for me. I follow the 2nd part of this case study, But now understand Ive to work on the 1st part too. Grateful to you Robbie. Cheers! Let me know how go. Thanks for such a wonderful proven track you have share with us, I really mean it.

I appreciate Michael too because of example of defamation their major role in this. Now Ive a reason, visible track most important things is result oriented approach, now Im going to work in a way which mean something I hope Ill get my desired result soon. Follow the process Aslam and Im sure youll see some great results. I love reading long and detailed post. Well, I must say that this one of the detailed post about seo case steady. Loved the minute details. This clearly explains the english investigation examples, time you took to publish this. Many hours went into this post. But, the how tall is dr, positive feedback makes it all worth it. Excellent case study. A great reminder of the english investigation, power of directories, resource and round up links.

Thanks Sam! Yes, those link sources are often overlooked, but provided a lot of satisfaction powerful backlink opportunities. English. Resource pages in particular, as evident in Michaels case study. This case study is the example, best thing i have read this week. The way you are guiding shows your command on investigation examples Inbound Methodology but also your sincerity to give some thing worthy to your readers. I am truly impressed by your efforts and i am expecting more informational posts in future. Plenty more to come Kashif! Credit goes to Michael on means this post. We try to make everything 100% actionable for our readers.

Glad to english language, see that coming through in the comments. Robbie,Just finished an epic guide its really great and actionable.I feel comfortable while reading the post and also apply for own site as well. Again thanks for how tall is dr jon lapook sharing such an english language investigation examples, amazing piece of content. Thanks Bilal! Glad you found it helpful. Let me know how the strategies work for you. Hello Robbie, thanks for your step-by-step guide in ranking website, I will use the strategy for my website http://www.pandapaperroll.com right away, hope it can work out. Cheers. Awesome Frank!

Let me know if you have any questions along the way. Cheers! Excellent article. This is something I honestly wish I would have put to market first. If I may add one aspect of of Mars honorable mention, its what I call binding keywords. We find binding keywords between buyer personas or core business pillars that act like a rudder for content. The idea behind the method is language investigation examples using Home Depot as an and Invasion Essay, example. English Language Investigation Examples. By applying branch logic, if someone looks for a paint brush, we assume they have a painting project on the horizon. What Does Means. We would offer them content regarding paint and english examples paint rollers, however we would label paint as a binding term and delineate content according to the content that fits into the same bucket. Further, we determine which buyer personas fill the need for the specified bucket of content, then apply cross linking between content offers AND workflows, segmenting to multiple lists. Assuming we view the process like a grid, this allows us to engage all three axis of content engagement, rather than two.

This is wonderful content. Thanks for The Perfect Gift: A Watch sharing. Thanks for the insight, Brad! Much appreciated. I take a similar approach when planning my content strategy for clients and language investigation examples personal projects. I refer to it as siloed content. Placing content into related buckets and carol salome then mapping the intent of those keywords different stages in the buyer journey. I was just running through links from my old company and re-read this article. What is truly amazing, is your forethought in english language investigation examples, the article, which holds water 1.5 years later. Does. Ive shown this article to multiple clients as an language investigation examples, example of how to keep their content on track for their designated verticals and what satisfaction content publishing.

Thanks again for english language investigation examples the great content. Awesome Bradley! Its an oldie, but a goodie Glad its been helpful. Thx so much for how tall is dr all of the tips. I found this article on VCB and glad I read it through (in doses). I had never throught about directory submissions for my blog posts and english language examples just submitted one to give it a try.

And, I went back to scoop.it which I hadnt used for a while. I love the The Story and Invasion, weekly or roundup idea, but I have not yet been successful in investigation examples, finding that for my area (hardwood flooring). But, I have hooked up w/ a few realtors doing some of these. Awesome, glad youre finding the case study helpful Debbie! Let us know if you have any questions. Thanks Michael and Robbie for this epic post. The key take away for me is the ease with which you turn what could be called boring niche blog posts into lead magnets. Many niche bloggers rarely collect emails but you have made email marketing seem very simple.Your conversion rates are much higher than IM industry average of 3% conversion. That is incredible. You have lit some light bulbs in me, now over to Scoop it which I have neglected for so long. International Relations. I got a link from R-TT after reading backlinko (Brian Dean).

Will surely check your other directory links. Keep up the good work. Awesome, glad you got some motivation/ ideas from the investigation, post Tom! Let me know how it goes. Here is a short tutorial to really ramp up your list building efforts: http://www.robbierichards.com/email/popup-upgrades/ Robbie, great article, and that UAV site is really next level.

Impressive work dude, thanks for international sharing. This is an english examples, epic post with so much to digest. There are so many gems here I feel like a fossicker who has just discovered buried treasure. Ive downloaded the ebook and will devour every morsel. Thanks Robbie for featuring Michaels richly detailed tutorial. Thanks Kim!

Glad you enjoyed the post. The Perfect Christmas Essays. Let us know how you go with it all. I have only One Question if u dont mind I heard and Learned from many sites around that Link Building Strategies had been changed over a year or two. Its now a days called PBN Era. Examples. If some people may not have enough money to Christmas Essays, buy a PBN or make it then the Online World is a waste of english language time for them ? Hey Usman, definitely not a waste of time. PBNs are just one way of building links and authority. But, be careful, if done incorrectly you can do more harm than good. Does Satisfaction. Check out Matt Woodwards PBN course if you want to go that route.

He has a lot of success with that strategy. Wow, I was searching for a pragmatic guide from english language examples keyword research to building links and I stumbled upon this. I believe I can really implement this strategy and rank for my desired keywords. I just got hit by a Google Manual Spam action and need to get out of it. This guide will surely help me to excel in my niche. Great post, youve earned yourself a hardcore subscriber. Cheers Sohaib! Glad you enjoyed the post.

Mind if I ask how you got the manual penalty duplicate content? Links? Thin content. Actually it was an neorealism relations, old site with reviews of 500 words each. I guess those days are over. I am now building sites from scratch with 2000+ reviews. and yeah I am eagerly waiting for language examples your December post :-).

Happy New Year Rob. Neorealism International Relations. Have a Blast. New case study going live on Thursday, Sohaib. Robbie, This is what actually Is looking for. Believe me, You just changed my whole mind #128512; Now, I think, I can pay with the million Dollar niches #128512; And oh yes, Im going to english language, take a challenge today. I will update with every month (Hope, you will see me).

Im going to take action end of neorealism international this year. Look forward to hearing about your progress, Tonmoy #128521; Solid post pal, it definitely shows that relevancy is everything these days, whether its onpage or offpage. Im also starting to do more again with blog comments, forum posts, high TF category pages on web directories and resource page links, in addtion to english language investigation, PBN links #128521; Cheers Dennis! Ive had a lot of and Invasion of Mars people mention they were focusing more on the PBN route. Very interesting.

Ive spoken to Matt Woodward about it a little. He swears by english investigation it, and of defamation after seeing some of language investigation examples his results, I can understand why. Very good article. Congratulations! Thanks guys! Glad you enjoyed the article. I hope you will find the means, time to write more articles per english investigation examples, month because they are terrific. Stefano from international Italy. Thanks Stefano! I appreciate that.

I have actually set a goal to write at least 300 words a day for the next 12 months straight. Language. This should help me double or triple the content production. Good stuff, I read this article a few weeks ago. I have got a question, I see that you are doing article submission and posting comment. My question is are there any SEO value in how tall jon lapook, it or you are just doing for eyeballs? Comment posting is english examples definitely more of an eyeballs strategy. Most links in the comment section these days are nofollow so they wont pass much link equity. However, commenting properly on large sites can definitely get you some targeted referral traffic. Wow, Great!

Ive really enjoyed your post. Does. Ive some questions please: Did you run any social media ads for that post? Did you build any backlinks from your competitors backlinks? I am eagerly waiting to hear from you. Again, thanks for sharing the great experience. No social media ads. No link building (yet)

Your screenshots and explanation are just awesome. This is the english language examples, best case study i read in recent days. Great post, but this spammy window! Hey Karol, thanks for stopping by the blog. Just to clarify, by window, are your referring to the opt-in popup form? Great post/case study Michael! love the in depth look at what you actually did to achieve results instead of the vague aerial view other guides give. I guess thats why Robbie shared it here! Personally I like to use Long Tail Pro for my keyword research. It makes it a lot easier and more efficient to and Invasion of Mars, find related keywords that arent too competitive.

Cheers Dominique! Im starting to test out Long Tail Pro as well. Action requires knweoldge, and now I can act! In what case do you have to follow Tiered backlinking. Please suggest, we are operate a digital marketing company. Quadrigo, I dont really worry about tiered link building.

I found your case study through some other guide on a blogging website and I can say its one of the best case studies I ever read. Giving out the URL and the exact strategies is english one of A Watch Essays things that people dont do. English Language Investigation. But you did it. I took few lessons from this post. thanks. i was amazed by The Story and Invasion of Mars Essay the content you created. English Language. iam an experienced marketer from a big marketing Brand in Holland but, this post really gave me some insight. Just wanted to thank you for this. Cheers BJ! Glad you enjoyed the and Invasion of Mars, post.

Wow, this is a great resource! I already have the Moz Chrome Extension, but I have never tried Ubersuggest. Examples. Im going to head over A Watch Essays there and play around with it. Wow, this is such an language examples, amazing article, the info and tips are pure gold, a million thanks for sharing this Robbie! Cheers mate! Glad you enjoyed it. wow, i was searching for SEO Case study on Google and of Mars Essay landed to this page, this is one of the best Guide, thanks for english sharing. Hi Robbie and neorealism Micheal, This is exceptional, really useful case study. I had to bookmark for later reading. Quora is english investigation sure an invaluable resource place for uncovering your audience pain; I started a blog recently and so far I have had just five posts on it.

All posts are direct answers to The Story Essay, users questions asked on Quora. Language Investigation. And from what I can tell, the result as been fair to carol ann duffy salome, say. The post are getting trickle traffic from english language examples search engine and carol ann duffy some significant impression. Examples. Consider that this is a blog less than 3weeks old with no links pointing to it. Thanks Micheal, youve share something really good with us. how much backlinks you made for single post? Ive built some articles that have over 200 RDs. Wow! Robbie, Hats off to you and carol ann duffy your posting. This is just amazing. Never seen such detail post ever as to Organic Link Building.

This is so precise and english language investigation examples descriptive that every SEO builder will be benefited. Thank you so much for this great post and awesome knowledge sharing. Thanks Harry. Credit to Mike Karp. Brilliant case study Robbie, even though it was published in 2015 which is a while in the world of satisfaction means SEO, there is still loads to learn there. Cheers for sharing the good content! Terrific case study.

It would take several days or perhaps a week for me to language investigation, create page like this one. Will certainly try to how tall, copy few things in my niche. Thank you very much. Robbie, really amazing case study, ever step is language investigation actionable, but I have a few questions, how do you write the article? can I outresource the example of defamation, article? how can I do that? This particular article was written by english language investigation examples a friend of mine Michael Karp. He is a great writer, and salome available for hide.

You can find Michael on english language investigation Twitter here @_MichaelKarp. Dude, great case study. This shows that the steps above work in what satisfaction means, every niche and english language investigation you only need hard work to make it possible. THis is the longest article that I ever read! :O seriously! anyway what you said about kw research and etc. are true, but to make very very long content! i think its not to important, as long the content are unique and giving differentiation and value to our reader is ann duffy more than enough , cause I heard some ppl giving suggestion its better to make 3-4 pages, rather than dump all article in english language investigation, one page! I think they right, because its to long. It can work to create a multi page post like Brian Dean did with his keyword research guide. It also depends on the niche. International. But, for the most part youre not going to get the high rankings with anything under 1500-2000 words.

Especially if looking at more top-mid funnel keywords. Ohh, Im new SEOER, I was searching for SEO Case study and landed to this page, this is one of the best Guide, I will try it. thanks for sharing. Let me know how it goes, Felix! Robbie, this is language investigation examples awesome the SEO case study, the Christmas A Watch, best SEO case study I have ever read. The way you explanations, hat off!! man, your time consuming research in investigation examples, a post is much appreciated. You are an inspiration. Keep it up man! Cheers mate! Appreciate the feedback.

Makes the late nights worth it. Hi Michael and Robbie. Thanks for sharing such an amazing guide. I was searching for ann duffy a step by step SEO case study. I stumbled here to find two amazing blogs. Got to learn about keyword research, on-page SEO etc from this awsome article.

I was researching about creating my own SEO strategy for all the blogs I handle. It would be great if any one of you can write a full step by step SEO template or system which people can follow as a protocol. Thanks for the kind words. Funny you mention that. Im actually working on a course concept right that aligns very closely with what you just described. Ill let you know when I have that finished. Hey Robbie, really enjoyed with this case study and uncovered couple of tips which I have never tested for content promotion (scoop) and Link building (Submiting On resources; weekly round ups). Language. WoW great tips, gonna test them out, I hope it will work more or less for ann duffy me as well. Thanks for sharing these Tips. Keep up the Great work if you have any other blog post similar to it about the same topic let me know, would love to dive in english language investigation examples, that.

Thanks Konstantine! You might want to check out the what satisfaction, latest blog post too. All my life Ive been creating content but not able to drive quality traffic, thanks to this comprehensive guide of yours Robbie. I will practice the way how you create content and will definitely replicate this case study in no time. Again hats off to you for sharing this stuff and Ill starting doing my research now so that I could create a good quality content. Cheers Vinson!

Glad youve found it helpful. Investigation. Reach out if you have any questions! Glad to help. Hi. Many thanks for your article, a great read and Ive taken away a couple of things that I hope to apply. I have a quick question, you mention that within your content that you include external links to high value related content. Yes I link out to what, helpful resources where it adds value. Whats your question? Cool case study. I really like the language, content creation part of the article. Your content should be better than all #1 page contents.

Haha cheers mate! Appreciate that. Hi, Its a brilliant article. The Story And Invasion Of Mars Essay. Great work. Thanks a lot. The SEO Case study is really amazing thank you so much for english examples sharing this information its useful for me.

Impressive stuff Robbie! I think using Buffer for social media posting offers slightly extra seo weight than ordinary posting. Worst thing about SEO is that it takes a lot of what satisfaction means time and investigation your post shows theres truth in that! Thanks Joe. Curious to hear more about your point of example of defamation using buffer to get extra SEO weight from social? Hey, Robbie Thanks for english language putting together a great article. Love the topic of drones as well!

I have never seen such an of defamation, excellent article written on Digital Marketing. As a beginner, reading through this material was a great learning. Examples. It increased depth of my knowledge and really inspired me. Thanking you for what does satisfaction an excellent piece. Glad it was helpful, Arpit! One of the best SEO Case Study Ive ever read. Thanks for language sharing and revealing your site mate. Ive got some ideas, Gonna Implement them. Awesome thank you!

Let me know how you go #128521; Printed out this bad boy! Thank you for creating such an and Invasion, amazing resource for the community to learn from. P.S.: I believe this is 11 thousand words long. Thanks Idris!

Youre prob right #128539; Its a monster! Hope you get some value from it.

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Alemtuzumab vs. Interferon Beta-1a in investigation Early Multiple Sclerosis. The CAMMS223 Trial Investigators * N Engl J Med 2008; 359:1786-1801 October 23, 2008 DOI: 10.1056/NEJMoa0802670. Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis. In this phase 2, randomized, blinded trial involving previously untreated, early, relapsingremitting multiple sclerosis, we assigned 334 patients with scores of 3.0 or less on the Expanded Disability Status Scale and a disease duration of 3 years or less to receive either subcutaneous interferon beta-1a (at a dose of 44 ?g) three times per week or annual intravenous cycles of alemtuzumab (at a dose of either 12 mg or 24 mg per day) for 36 months. In September 2005, alemtuzumab therapy was suspended after immune thrombocytopenic purpura developed in three patients, one of whom died. Treatment with interferon beta-1a continued throughout the neorealism, study. Alemtuzumab significantly reduced the english language investigation, rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. 26.2%; hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.001) and the annualized rate of relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0.001). The mean disability score on a 10-point scale improved by 0.39 point in carol ann duffy the alemtuzumab group and worsened by 0.38 point in examples the interferon beta-1a group (P0.001).

In the alemtuzumab group, the lesion burden (as seen on T 2 -weighted magnetic resonance imaging) was reduced, as compared with that in the interferon beta-1a group (P=0.005). From month 12 to is dr jon lapook month 36, brain volume (as seen on T 1 -weighted magnetic resonance imaging) increased in the alemtuzumab group but decreased in english examples the interferon beta-1a group (P=0.02). Adverse events in the alemtuzumab group, as compared with the interferon beta-1a group, included autoimmunity (thyroid disorders [23% vs. 3%] and immune thrombocytopenic purpura [3% vs. 1%]) and infections (66% vs. 47%).

There were no significant differences in The Perfect Christmas Gift: A Watch outcomes between the 12-mg dose and the 24-mg dose of alemtuzumab. In patients with early, relapsingremitting multiple sclerosis, alemtuzumab was more effective than interferon beta-1a but was associated with autoimmunity, most seriously manifesting as immune thrombocytopenic purpura. The study was not powered to identify uncommon adverse events. (ClinicalTrials.gov number, NCT00050778.) Multiple sclerosis typically follows a relapsingremitting course, but most patients eventually convert to a secondary progressive phase characterized by deficits that increase in the absence of language further relapses. Is Dr! This clinical evolution reflects the english examples, complex interplay of focal inflammation, demyelination, and axonal degeneration in The Perfect Christmas A Watch Essays the central nervous system. Current disease-modifying treatments decrease the frequency of language relapse and modestly reduce the accumulation of disability but have not been shown to prevent secondary progression. 1 New agents that combine improved efficacy with acceptable safety need to be identified.

The humanized monoclonal antibody alemtuzumab (Campath-1H; Campath, or MabCampath; Genzyme) targets CD52 on lymphocytes and monocytes. Pulsed administration causes prolonged T-cell depletion and modulation of the lymphocyte repertoire. Does! 2. Since 1991, studies of alemtuzumab in the treatment of examples patients with secondary progressive multiple sclerosis have suggested efficacy in the suppression of relapse but not in preventing the continued progression of disability. What Does! 3 Although few infections occurred, autoimmunity developed in some patients several months after administration of the drug. 4 Subsequent open-label studies in relapsingremitting disease showed that alemtuzumab stabilized and even improved existing deficits. 2 On the basis of these observations emerged hypotheses that the secondary progressive phase of the disease might be attributable to postinflammatory neurodegeneration and that immunotherapy would influence long-term disability only if administered early in the disease course. These concepts informed the design of our blinded, phase 2, randomized trial comparing two doses of alemtuzumab with subcutaneous interferon beta-1a (Rebif, EMD Serono and Pfizer) in previously untreated patients with early, relapsingremitting multiple sclerosis.

From December 2002 to July 2004, a total of 334 patients underwent randomization at 49 centers in Europe and the United States. English! The last patient started treatment in salome September 2004. Each patient provided written informed consent. Eligibility criteria were a diagnosis of relapsingremitting multiple sclerosis (on the basis of the McDonald criteria 5 ) with an onset of symptoms no more than 36 months before the time of screening; at least two clinical episodes during the previous 2 years; a score of 3 or less on the Expanded Disability Status Scale (EDSS), 6 which ranges from 0 to 10, with higher scores indicating greater disability; and one or more enhancing lesions, as seen on at least one of up to four monthly cranial magnetic resonance imaging (MRI) scans. Key exclusion criteria were previous disease-modifying treatments, a history of clinically significant autoimmunity, or the presence of serum antithyrotropin-receptor antibodies. Eligible patients were randomly assigned in language investigation a 1:1:1 ratio to receive alemtuzumab (at a dose of either 12 mg per jon lapook day or 24 mg per day) or interferon beta-1a with the use of the Pocock and Simon minimization algorithm 7 to balance the study groups with regard to age (30 years or ?30 years), sex, and baseline EDSS score (2.0 or ?2.0). Alemtuzumab was given by intravenous infusion on english investigation examples 5 consecutive days during the first month and on 3 consecutive days at months 12 and 24 (the latter at of defamation the treating physicians' discretion if the CD4+ T-cell count was ?100?10 6 cells per language examples liter). Interferon beta-1a (at a dose of 44 ?g) was administered subcutaneously three times weekly after dose escalation. Example Of Defamation! All patients received 1 g of intravenous methylprednisolone for 3 days at baseline and at months 12 and 24, coinciding with infusion cycles as premedication for those receiving alemtuzumab.

Some patients also received antihistamines or antipyretics at the investigators' discretion. Investigation! EDSS scores were determined quarterly in a blinded fashion by a neurologist who also adjudicated possible relapses. Patients wore clothing that covered injection sites. The effectiveness of blinding was assessed at the end-of-study visit. Safety was assessed quarterly by the treating neurologist, who was aware of study-group assignment. The coprimary measures of efficacy were the time to sustained accumulation of disability and is dr, the rate of relapse. Disability was assessed according to the ordinal EDSS score.

A sustained accumulation of disability was defined as an increase of at least 1.5 points for patients with a baseline score of 0 and of at least 1.0 point for patients with a baseline score of 1.0 or more; all scores were confirmed twice during a 6-month period. Language Investigation! The onset of a sustained level of disability was timed to the first recorded increase in how tall is dr the EDSS score aside from relapse. Patients with an increased level of disability could be discontinued from the study. A relapse was defined as new or worsening symptoms with an objective change in neurologic examination attributable to multiple sclerosis that lasted for at least 48 hours, that were present at language investigation normal body temperature, and that were preceded by at least 30 days of clinical stability. Secondary outcomes were the proportion of The Story patients who did not have a relapse, changes in lesion burden (as seen on T 2 -weighted MRI), and brain volume (as measured by the Losseff method on T 1 -weighted MRI 8 ). MRI scans were performed annually and interpreted by a neuroradiologist at Perceptive Informatics who was unaware of assignments to study groups. Thyroid function and levels of english investigation examples antithyrotropin-receptor antibodies and lymphocyte subpopulations were measured quarterly at a central laboratory (Cirion Clinical Trial Services and Charles River Laboratories). Serum-binding antibodies against alemtuzumab were measured with the use of a validated enzyme-linked immunosorbent assay (ELISA) 9 at neorealism international BioAnaLab. There was no active monitoring for progressive multifocal leukoencephalopathy.

Criteria for the diagnosis of immune thrombocytopenia were a single confirmed platelet count of fewer than 50,000 per microliter without clumping or a platelet count of more than 50,000 but fewer than 100,000 per microliter on at least two consecutive occasions during a period of at least 1 month, with normal hemoglobin, neutrophil, and eosinophil counts; an absence of splenomegaly; and a normal peripheral-blood smear (apart from thrombocytopenia). All adverse events with an onset up to 36 months are reported. In addition, all serious adverse events and autoimmune-associated disorders occurring before March 1, 2008, are listed. A subsequent adverse event of Burkitt's lymphoma not associated with EpsteinBarr virus (EBV) is also included in this report. On the basis of the literature, 2-16 we determined that 285 patients would be needed to provide a power of english investigation 75% to detect a treatment effect at 36 months, assuming a rate of sustained disability of 12% in the alemtuzumab group and of 30% in The Story and Invasion Essay the group receiving interferon beta-1a with a two-sided test and a significance level of 2% (with a Bonferroni adjustment for two alemtuzumab groups and a significance level of 1% for english language investigation examples, the comparison of relapse rates).

After reaching this recruitment target, 49 of 75 patients who were already being screened subsequently underwent randomization. Preplanned interim analyses were performed when most patients had completed at least 1 year and 2 years with a prespecified alpha spending function. International Relations! Disclosure of these results formed part of safety announcements by english examples the sponsor in September 2005 and The Perfect Gift: A Watch Essays, 2006. After the interim analyses, P values of less than 0.016 and 0.004 were considered to have statistical significance for english, the rates of sustained disability and relapse, respectively (for details, see the Supplementary Appendix, available with the does, full text of this article at www.nejm.org). Language! Treatment effects were compared with respect to the time to sustained accumulation of disability with the use of a proportional-hazards model and to the rate of relapse with the use of the The Perfect, AndersenGill model with robust variance estimation. English Investigation! 10 Covariates for salome, these models included study-group indicators, country, and baseline EDSS score. The proportion of patients with relapse-free survival was assessed with the use of logistic regression. The estimated percentage of english patients with sustained disability or relapse was generated by Christmas A Watch Essays the KaplanMeier method.

The annualized rate of relapse was estimated with the use of Poisson regression. The number of patients who would need to english be treated with alemtuzumab instead of interferon beta-1a to carol salome prevent one patient from having a relapse or sustained disability was calculated according to the proportion of english investigation patients who did not have these outcomes at month 36. 11 Comparisons of of defamation EDSS scores were based on a repeated-measures analysis of covariance. A proportional-odds model was used to estimate improvement, stabilization, and worsening of the english investigation, EDSS score, as compared with baseline. The percent change from baseline on Christmas Gift: Essays MRI was analyzed with the use of the WilcoxonMannWhitney test and english language, the multivariate WeiLachin test 12,13 during the how tall is dr jon lapook, entire 36-month period. For the rate of sustained disability, a sensitivity analysis was conducted that limited the required period for an increased EDSS score to 3 months. Fisher's exact test and Poisson regression were used for investigation examples, the analysis of adverse events and Christmas Gift:, event rates, respectively. The reported P values are two-sided and were not adjusted for multiple testing. In addition to the comparisons between two alemtuzumab groups and the group receiving interferon beta-1a, comparisons of the pooled alemtuzumab groups and the group receiving interferon beta-1a are reported.

The pooling of the alemtuzumab groups was not prespecified in the statistical analysis plan. The protocol was designed by the lead academic authors and was approved by local review boards or the english language investigation examples, ethics committee at each center. Genzyme employees analyzed the data in accordance with the statistical plan and with additional suggestions from the writing committee. The analyses were ratified by two independent statisticians at Boston University. The conduct of the study was monitored by an independent data and safety monitoring board. The lead academic authors vouch for the completeness and carol salome, veracity of the data and analyses. Of 334 patients who underwent randomization, 111 were assigned to receive subcutaneous interferon beta-1a three times weekly, and 223 were assigned to receive annual cycles of alemtuzumab, with 113 receiving 12 mg per day and 110 receiving 24 mg per day.

One patient who received alemtuzumab was included in the safety analysis but was excluded from the efficacy analyses because the initial diagnosis of multiple sclerosis was incorrect, and the patient received the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) during the study. Baseline demographic and english language examples, clinical characteristics were similar in the three treatment groups ( Table 1 Table 1 Baseline Characteristics of the Patients. ). Neorealism International Relations! The enrollment and outcomes of patients are shown in Figure 1 Figure 1 Enrollment and Outcomes. . The absence of an enhancing lesion on initial MRI scans was the commonest cause of screening failure. English Investigation Examples! In September 2005, the what does means, data and english investigation examples, safety monitoring board recommended suspension of alemtuzumab treatments after receiving reports of three cases of neorealism international relations immune thrombocytopenic purpura, including one death. All safety and efficacy assessments proceeded as planned, and patients who were receiving interferon beta-1a continued to receive the drug. At the time of dose suspension, only 2 eligible patients (1%) had not received the second cycle of english alemtuzumab at month 12, whereas 155 patients (75%) were precluded from receiving the third cycle of alemtuzumab at month 24. We implemented a program to ensure prompt identification and appropriate management of immune thrombocytopenic purpura. This program included education for patients and physicians, monthly blood counts, and regular contact with patients, which included discussion about symptoms and signs of The Story of Mars immune thrombocytopenic purpura.

Three more patients with immune thrombocytopenic purpura were identified in December 2005, July 2006, and September 2006. Asymptomatic, chronic immune thrombocytopenic purpura developed in one patient who was receiving interferon beta-1a. More patients discontinued interferon beta-1a than alemtuzumab, principally because of a lack of efficacy and adverse events, so that only english language examples, 59% of the original group of patients receiving interferon beta-1a completed the 36-month study, as compared with 83% of patients receiving alemtuzumab. At the end of the study review, 90% and 91% of raters remained unaware of assignments to the group receiving interferon beta-1a and the group receiving alemtuzumab, respectively. There were no significant differences between the groups receiving either 12 mg or 24 mg of what means alemtuzumab on any outcome measure or adverse event. Therefore, data pooled from both alemtuzumab groups are presented, together with a breakdown according to dose. As compared with interferon beta-1a, alemtuzumab reduced the risk of sustained disability by 71% (hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0. 001) ( Table 2 Table 2 Measures of Disability, Relapse, and Radiologic Outcomes. and Figure 2A Figure 2 Efficacy Outcome Measures Regarding Disability and Relapse at 36 Months. Panel A shows KaplanMeier curves for language investigation, patients who reached the criteria for sustained accumulation of disability. Panel B shows the cumulative number of relapses. Panel C shows the estimated mean score on the Expanded Disability Status Scale (EDSS, which ranges from 0 to 10, with higher scores indicating greater disability) on the basis of repeated-measures analysis of The Perfect Christmas A Watch Essays covariance.

The vertical lines represent 95% confidence intervals. Panel D shows the annualized relapse rate from baseline to 36 months for language examples, 222 patients who received alemtuzumab and Christmas A Watch, from month 24 to month 36 for 97 patients who received alemtuzumab for two cycles and 45 patients who received alemtuzumab for three cycles. Also shown are annualized rates of language relapse from baseline to month 36 for 111 patients who received interferon beta-1a and from month 24 to month 36 for and Invasion Essay, 74 patients who received interferon beta-1a. The annualized relapse rates were estimated with the use of Poisson regression analysis separately for patients who received a third cycle of english language investigation therapy and for those who did not receive a third cycle. The analyses of month 24 to month 36 were restricted to patients with follow-up during that period. The vertical lines represent standard errors. ). For the A Watch Essays, 12-mg dose, the risk of sustained disability was reduced by 75% (hazard ratio, 0.25; 95% CI, 0.11 to 0.57; P0.001); for the 24-mg dose, the risk reduction was 67% (hazard ratio, 0.33; 95% CI, 0.16 to 0.69; P=0.003). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to avoid one sustained disability event during the 36-month period was 5.8 (5.6 for the 12-mg dose and 6.0 for the 24-mg dose).

In sensitivity analysis of the risk of language investigation examples sustained disability at 3 months, the risk reduction was 64% (hazard ratio, 0.36; 95% CI, 0.21 to what satisfaction means 0.60; P0.001). In both alemtuzumab groups, the mean disability score on examples the EDSS, which was 1.9 points at jon lapook baseline, improved by 0.39 point (95% CI, 0.23 to 0.55) at 36 months: 0.32 point for the 12-mg dose (P=0.006) and 0.45 point for the 24-mg dose (P=0.001). During the same time, the mean disability score worsened by 0.38 point (95% CI, 0.13 to 0.63) among patients receiving interferon beta-1a, representing a net advantage of 0.77 point (95% CI, 0.48 to 1.06; P0.001) among patients receiving alemtuzumab ( Table 2 and Figure 2C ). As compared with interferon beta-1a, the estimated odds ratio for worsening disability versus either improved or stable disability was 0.41 (95% CI, 0.24 to 0.69) for the 12-mg dose of alemtuzumab and 0.33 (95% CI, 0.19 to 0.56) for the 24-mg dose (P0.001 for both comparisons). As compared with interferon beta-1a, alemtuzumab reduced the rate of english language relapse by 74% (hazard ratio, 0.26; 95% CI, 0.16 to carol 0.41; P0. 001) ( Table 2 and Figure 2B ); both alemtuzumab doses were effective, with a reduction of 69% (95% CI, 48 to language 82) for the 12-mg dose and 79% (95% CI, 60 to 89) for the 24-mg dose (P0.001 for both comparisons).

The annualized relapse rate at 36 months was 0.36 for interferon beta-1a and 0.10 for alemtuzumab (0.11 for the 12-mg dose and 0.08 for the 24-mg dose). The proportion of patients who remained relapse-free at 36 months was 52% for interferon beta-1a and 80% for alemtuzumab (77% for the 12-mg dose and 84% for the 24-mg dose; P0.001 for both comparisons) ( Table 2 ). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to prevent 1 patient from carol ann duffy salome, having a relapse at 36 months was 3.5 (3.9 and 3.1 for language, the 12-mg dose and 24-mg dose, respectively). There were no significant differences in safety or treatment effect on disability between patients receiving two cycles of alemtuzumab and those receiving three cycles of the The Perfect Christmas A Watch, drug. However, there was evidence of the english, waning of treatment efficacy on the rate of relapse. The annualized rate of relapse in ann duffy salome 161 patients who received two cycles of language investigation examples alemtuzumab was 0.16 in months 24 to 36, an increase from 0.07 for months 0 to 12 and 0.06 for months 12 to 24. This rate was significantly reduced, as compared with the rate of 0.34 in patients receiving interferon beta-1a between months 24 and 36 (P=0.01). Among 45 patients who received three cycles of alemtuzumab, there was only one relapse between months 24 and example of defamation, 36 ( Figure 2D ). English Language Investigation! From baseline to 36 months, there was a reduction in the volume of lesions, as seen on The Perfect Christmas Gift: T 2 -weighted MRI, in all three study groups ( Table 2 ). The reduction was more marked after treatment with alemtuzumab than with interferon beta-1a (P=0.005), with significant reductions from english language investigation, baseline at months 12 (P=0.01) and example of defamation, 24 (P=0.005). The differences in median change at english month 36 were not significant.

Of note, the sample size for the 36-month analyses was reduced because of the Gift: A Watch, number of patients who discontinued the study and the 26 patients who had missing or technically deficient MRI scans. The reduction in brain volume between baseline and month 36 was significantly less among patients receiving alemtuzumab than among those receiving interferon beta-1a (?0.5% and ?1.8%, respectively; P=0.05). English! Recognizing that atrophy measures may be confounded by early suppression of inflammatory space-occupying lesions, we analyzed brain volume between months 12 and 36; this measure was reduced by is dr jon lapook 0.2% among patients receiving interferon beta-1a but was increased by 0.9% in those receiving alemtuzumab (P=0.02) ( Table 2 ). On clinical and MRI outcomes, alemtuzumab remained superior to language examples interferon beta-1a after subgroup analyses according to study-site location, baseline EDSS score, lesion load on T 2 -weighted MRI, cerebral volume on T 1 -weighted MRI, sex, race, and age of patients (data not shown). Neorealism Relations! Almost all patients reported at least one adverse event, and the number who had serious adverse events was also similar among the three study groups ( Table 3 Table 3 Adverse Events (Safety Population). and investigation, the Supplementary Appendix). There were two deaths, both in of defamation the alemtuzumab group. One patient who had several preexisting cardiac risk factors died of english investigation examples cardiovascular disease. The other death was attributable to immune thrombocytopenic purpura.

Three cancers (nonEBV-associated Burkitt's lymphoma, breast cancer, and cervical cancer in situ) were reported in Essays patients in the alemtuzumab group, with onset ranging from 22 to 64 months after the first annual cycle; among patients receiving interferon beta-1a, one case of colon cancer was reported at 36 months ( Table 3 ). Serious infusion reactions occurred in three patients (1.4%) in the alemtuzumab group and led to discontinuation in one patient (0.5%). Localized injection-site reactions were common among patients receiving interferon beta-1a and led to discontinuation in two patients (1.9%). Abnormal liver-function tests were seen in 2.3% of patients in the alemtuzumab group and in 15.0% of those receiving interferon beta-1a, causing discontinuation of examples interferon beta-1a in three patients and grade 4 hepatic failure in one patient. Mild-to-moderate infections, especially of the example of defamation, respiratory tract, were more common among patients in the alemtuzumab group than in those receiving interferon beta-1a. Recurrent oral herpes simplex virus type 1 was seen in three patients immediately after each cycle of alemtuzumab. Inactive tuberculosis was identified incidentally in one patient receiving the 24-mg dose of alemtuzumab. No cases of progressive multifocal leukoencephalopathy, cytomegalovirus, or pneumocystis pneumonia were reported. Language Investigation! Immune thrombocytopenic purpura developed in six patients (2.8%) receiving alemtuzumab and one patient (0.9%) receiving interferon beta-1a (P=0.43). The index patient suffered a fatal brain hemorrhage before diagnosis. In retrospect, cutaneous signs of immune thrombocytopenic purpura had been present for several weeks but went unreported. Of the six patients receiving alemtuzumab in whom immune thrombocytopenic purpura developed, four were receiving the 24-mg dose (three patients after two cycles and one after three) and two were receiving the 12-mg dose (both after three cycles).

Remission of immune thrombocytopenic purpura occurred without treatment in example one patient, after corticosteroid therapy in two patients, and after rituximab therapy in two patients. Grade 2 thrombocytopenia developed in one patient after 3 months of english language examples receiving interferon beta-1a; the condition persisted despite the withdrawal of interferon beta-1a and remained at grade 1 at of defamation the end of the study after reintroduction of interferon beta-1a. Adverse events affecting the thyroid were more frequent in the alemtuzumab group than in the group receiving interferon beta-1a (49 vs. Investigation! 3) ( Table 3 ); these events were associated with thyroid autoantibodies in 96% of The Perfect Christmas affected patients and occurred up to 30 months after the last dose of language examples a study drug. What Does! Three patients (1.4%) in the alemtuzumab group had serious hyperthyroid events, and 32 patients had hyperthyroidism, including 25 with sustained hyperthyroidism. Others had transient hyperthyroidism followed by normalization (four patients), sustained hypothyroidism (six), or hypothyroidism followed by hyperthyroidism (two). Examples! Four patients underwent thyroid ablation with radioactive iodine, and 24 were treated with antithyroid agents (3 only Essays, temporarily).

Primary hypothyroidism developed in 10 patients. In total, 18 patients required long-term thyroid-replacement therapy. Graves' ophthalmopathy developed in one patient after radioactive iodine ablation. (Numbers of patients were derived from in-depth case analyses and may differ from language examples, numbers of adverse events reported by neorealism investigators, as listed in Table 3 .) Alemtuzumab rapidly depleted lymphocytes after each treatment cycle. Lymphocyte reconstitution was similar for english language investigation examples, both doses. Does Satisfaction! B-cell numbers returned to normal between 3 and 6 months. T-cell counts rose slowly and english investigation examples, remained subnormal for the duration of the study; the median time for recovery of CD4+ lymphocytes was 3 months for 100?10 6 cells per liter; the time ranged from 6 to 9 months for 200?10 6 cells per liter. Alemtuzumab-binding antibodies above the prespecified threshold of 2000 U per ann duffy salome milliliter were detected in 1 of 208 patients (0.5%) and 51 of 194 patients (26.3%) at 12 and 24 months, respectively. Language! The presence of these antibodies had no apparent effect on efficacy, infusion-associated reactions, lymphocyte depletion, or repopulation. Among previously untreated patients with early, relapsingremitting multiple sclerosis, alemtuzumab reduced the is dr jon lapook, risk of sustained accumulation of disability by 71% and the risk of relapse by 74% (P0.001 for both), as compared with interferon beta-1a.

Efficacy was maintained over language investigation examples 36 months, even though 72% of does means alemtuzumab-treated patients did not receive the planned third cycle of therapy at month 24 because of investigation safety concerns. The reduction in the lesion load on T 2 -weighted MRI was greater among patients receiving alemtuzumab than among those receiving interferon beta-1a, although the difference at 36 months was not significant; comparisons were limited by missing MRI data and the high discontinuation rate for interferon beta-1a. And Invasion Of Mars Essay! This apparent superior efficacy of alemtuzumab was not due to poor response to interferon beta-1a, since the relapse rate among patients receiving interferon beta-1a was lower than that seen in the licensing studies. 14-18 The infusion-related syndrome associated with alemtuzumab precluded double-blinding. 19 Therefore, we used a rater who was unaware of treatment assignments for efficacy outcomes, as advocated by the American Academy of Neurology, 20 and confirmed successful maintenance of english blinding throughout the study. International! Although our study suggests that alemtuzumab is more effective than interferon beta-1a when given at the earliest stages of relapsingremitting multiple sclerosis, our findings raise the difficult issue of exposing young adults who have little disability to a drug having potentially serious adverse effects. Our phase 2 trial was not designed to language assess the example, long-term safety of alemtuzumab, nor was it powered to detect uncommon adverse events. However, the trial was larger and longer than other recent phase 2 trials 21,22 and, unlike them, used an active licensed comparator. Investigation! To date, the major safety concern is autoimmunity, already known to example be a generic complication of immune reconstitution from lymphocytopenia. 23,24 Thyroid autoimmunity was observed, as reported previously.

4. Immune thrombocytopenic purpura caused the language, death of The Perfect Gift: Essays one patient. After the report of two further cases, the data and safety monitoring board suspended the administration of alemtuzumab between September 2005 and May 2007. Risk minimization measures effectively identified subsequent patients with immune thrombocytopenic purpura, and such measures should be considered mandatory for english language, the safe future use of alemtuzumab. Immune thrombocytopenic purpura was seen in 2.8% of patients receiving alemtuzumab and 0.9% of those receiving interferon beta-1a. A Watch! An association between immune thrombocytopenic purpura and multiple sclerosis has recently been identified. 25-28 Immune thrombocytopenic purpura has also been reported after the administration of alemtuzumab in the context of hematopoietic stem-cell transplantation and for other conditions. 29-31 There is insufficient information to draw conclusions regarding the english, risk of cancer associated with alemtuzumab in this population, since cancer was diagnosed in Christmas Gift: A Watch three patients in the alemtuzumab group and investigation examples, one patient receiving interferon beta-1a. Mean disability scores improved among patients in the alemtuzumab group, as first seen in our open-label study of alemtuzumab, 2 but worsened among those receiving interferon beta-1a.

If improvements in disability after alemtuzumab are sustained, there would be important implications for neorealism international relations, the management of multiple sclerosis. An improvement of 0.39 EDSS point from a baseline score of 2.0 points represents a shift from minimal disability to abnormal neurologic signs without disability. English Language Investigation! This clinical change was matched by an increase in brain volume on T 1 -weighted MRI between months 12 and 36, whereas brain atrophy advanced among patients receiving interferon beta-1a. A possible mechanism may be the secretion of neurotrophins by lymphocytes that are regenerated after the international relations, administration of alemtuzumab. 32 Together, these findings support the hypothesis that early suppression of inflammation in multiple sclerosis inhibits the complex cascade of disease mechanisms responsible for long-term disability. Supported by english examples Genzyme and Bayer Schering Pharma. Christmas Gift: A Watch Essays! Dr. Coles reports receiving consulting and lecture fees and language investigation, grant support from example of defamation, Genzyme; Dr. English! Compston, receiving consulting and international, lecture fees and grant support from Genzyme and lecture fees from Bayer Schering Pharma; Dr. Selmaj, receiving consulting fees from Genzyme, Biogen Idec, and Biopartners and lecture fees from Schering, Novartis, and Biogen Idec; and Drs. Lake, Moran, Margolin, and Tandon and Ms.

Norris, being employees of Genzyme and language investigation examples, having an equity interest in example the company. No other potential conflict of interest relevant to language examples this article was reported. The members of the writing group (Alasdair J. Coles, Ph.D., F.R.C.P., and neorealism international relations, D. Alastair S. Language Investigation! Compston, F.Med.Sci., Ph.D., University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Krzysztof W. Selmaj, M.D., Ph.D., Department of Neurology, Medical University of Lodz, Lodz, Poland; and what means, Stephen L. Lake, Sc.D., Susan Moran, M.D., M.S.C.E., David H. Margolin, M.D., Ph.D., Kim Norris, B.Sc., and P.K. Tandon, Ph.D., Genzyme, Cambridge, MA) assume responsibility for the overall content and integrity of the article. We thank the language examples, following Genzyme employees for their assistance in study operations and ann duffy salome, data analysis: D. Boisvert, R. Clark, R. Dhanjal, J. Haas, O. Haider, A. Feleaga, K. Hoffman, G. Newgard, T. Rios, M. Rizzo, and Q. English Investigation Examples! Yu. Address reprint requests to Drs. Coles and Compston at the Department of Neurology, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom, or at ajc1020@medschl.cam.ac.uk or alastair.compston@medschl.cam.ac.uk. Investigators in the International Campath-1H in The Perfect Multiple Sclerosis (CAMMS223) trial are listed in the Appendix. The following researchers participated in the study: Data and Safety Monitoring Board: H. Panitch (chair), University of Vermont, Burlington; E. Anaissie, University of Arkansas for Medical Sciences, Little Rock; D. Cines, University of Pennsylvania, Philadelphia; L. English Examples! DeGroot, Brown University, Providence, RI; F. Dorsey, Franklin, ME; T. How Tall Jon Lapook! Phillips, Texas Neurology, Dallas; J. Simon, Portland Veterans Affairs Medical Center, Portland, OR. Investigators and english examples, Study Centers: Croatia: V. Brinar (principal investigator), Clinical Hospital Center Zagreb, Zagreb; V. Demarin (principal investigator), Sestre Milosrdnice University Hospital, Zagreb; D. The Perfect Gift: Essays! Janculjak (principal investigator), Clinical Hospital Osijek, Osijek; J. Rudez (principal investigator), Clinical Hospital Center Rijeka, Rijeka; A. Vladic (principal investigator), General Hospital Sveti Duh, Zagreb; Poland: A. Czlonkowska (principal investigator), D. Mirowska-Guzel, Institute of Psychiatry and Neurology, Warsaw; W. English! Kozubski (principal investigator), Medical Academy (Poznan), Poznan; H. Carol Salome! Kwiecinski (principal investigator), Warsaw Medical University, Warsaw; K. Language! Selmaj (principal investigator), Katedra i Klinika Neurologii Akademii, Lodz; Z. Stelmasiak (principal investigator), Katedra i Klinika Neurologii, Lublin; A. Szczudlik (principal investigator), Klinika Neurologii, Krakow; Russia: A. Boyko (principal investigator), Moscow MS Center, Moscow City Hospital 11, Moscow; E.I.

Gusev (principal investigator), Russian State Medical University, Moscow; A. Skoromets (principal investigator), St. Petersburg State Pavlov Medical, St. Petersburg; I. Stolyarov (principal investigator), Institute of the Human Brain, St. Petersburg; N. Yakhno (principal investigator), Moscow City Hospital 61, Moscow; I. How Tall Jon Lapook! Zavalishin (principal investigator), Neurology Research Institute, Moscow; United Kingdom: A.J. Coles (principal investigator), D.A.S. Compston (principal investigator), J. Shawcross, J. English Language Investigation! Jones, A.L.

Cox, Addenbrooke's Hospital, Cambridge; United States: A. Bass (principal investigator), D. Wenzel, Neurology Center of San Antonio, San Antonio, TX; V. Biton (principal investigator), Clinical Trials, Little Rock, AR; M. Cascione (principal investigator), Axion Clinical Research of Florida, Tampa; B. Cleeremans (principal investigator), NervePro Research, Irvine, CA; J. Cooper (principal investigator), East Bay Physicians Medical Group, Berkeley, CA; P.K. Coyle (principal investigator), D. Madigan, SUNY at Stony Brook, Stony Brook, NY; B. Cutler (principal investigator), Cancer Research Network, Plantation, FL; E.J. Fox (principal investigator), L. Mayer, R. Tyer, Central Texas Neurology Consultants, Round Rock; S. Gazda (principal investigator), Integra Clinical Research, San Antonio, TX; S. Glyman (principal investigator), Nevada Neurological Consultants, Henderson; A. Gupta (principal investigator), Fort Wayne Neurological Center, Fort Wayne, IN; J. And Invasion Of Mars! Harney (principal investigator), Dallas Neurological Associates, Richardson, TX; G. Hutton (principal investigator), Baylor College of Medicine, Houston, TX; D. English Language! Jacobs (principal investigator), Neurological Services of Orlando, University of Central Florida College of Medicine, Orlando; O. Khan (principal investigator), R. Lisak, A. Tselis, Wayne State University School of Medicine, Detroit; J. Klapper (principal investigator), Colorado Neurology and Headache Center, Denver; J. Liss (principal investigator), Medical Research and Health Education, Columbus, GA; D. Meyer (principal investigator), All-Trials Clinical Research, Winston-Salem, NC; A. Rae-Grant (principal investigator), Lehigh Valley Hospital Neurosciences, Allentown, PA; H. Rossman (principal investigator), W. Boudouris, M. Belkin, R. Pierce, Michigan Institute for Neurological Disorders, Farmington; W. Royal (principal investigator), University of Maryland, Baltimore; R. Means! Shubin (principal investigator), D. Sider, Neuro-Therapeutics, Pasadena, CA; M. Stein (principal investigator), MS Service, Walnut Creek, CA; B. Steingo (principal investigator), Neurological Associates, Pompano Beach, FL; H. Sullivan (principal investigator), Michigan Medical, Grand Rapids; C. Twyman (principal investigator), Associates in Neurology, Lexington, KY; R. Webb (principal investigator), Neurological Associates of Tulsa, Tulsa, OK; B. Weinshenker (principal investigator), B.M. Keegan, D. Rauchwarter, Mayo Clinic, Rochester, MN; D. Wingerchuk (principal investigator), J. Carter, Mayo Clinic Arizona, Scottsdale; S. English Language Examples! Wray (principal investigator), Knoxville, TN; D. Wynn (principal investigator), N. Allen, C. Nagar, D. Example! O'Brien, Consultants in Neurology, Northbrook IL. MRI Central Reading Center: J. Paskavitz, Perceptive Informatics, Waltham, MA; P. Schaefer, Massachusetts General Hospital, Boston. Thyroid Advisory Panel: L. DeGroot, Brown University, Providence RI; W. English Language Examples! Valente, University of Maryland School of Medicine, Baltimore. Immune Thrombocytopenic Purpura Advisory Panel: D. Beardsley, Yale University School of Medicine, New Haven, CT; J. Bussel, Weill Cornell Medical College of Cornell University, New York; D. Cines, University of Pennsylvania, Philadelphia; M. Goldberg, Genzyme, Cambridge, MA; R. MacMillan, Scripps Cancer Center, La Jolla, CA; D. Scadden, Massachusetts General Hospital, Boston. Independent Statisticians: R.B. D'Agostino, M. Pencina, Boston University, Boston. Study Manager: G. Gonzales, Genzyme.

Scientific Advisers: H. Waldmann, G. Hale, University of and Invasion of Mars Essay Oxford, Oxford, United Kingdom. Compston A, Coles A. Multiple sclerosis. Language Investigation! Lancet (in press). Coles AJ , Cox A , Le Page E , et al. Example Of Defamation! The window of therapeutic opportunity in english language examples multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol 2006;253:98-108. Moreau T , Thorpe J , Miller D , et al. Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis. Lancet 1994;344:298-301[Erratum, Lancet 1994;344:486.] Coles AJ , Wing MG , Smith S , et al. Pulsed monoclonal antibody treatment and what does means, autoimmunity thyroid disease in multiple sclerosis.

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Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 1996;119:225-237. Goodin DS , Frohman EM , Garmany GP Jr , et al. Disease modifying therapies in multiple sclerosis: report of the what does satisfaction, Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology 2002;58:169-178[Erratum, Neurology 2002;59:480.] Hauser SL , Waubant E , Arnold DL , et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008;358:676-688. Kappos L , Antel J , Comi G , et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis.

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Prevalence of ann duffy salome other autoimmune diseases in patients with multiple sclerosis. Mult Scler 2005;11:S29-S29. Granier H , Bellard S , Nicolas X , Laborde JP , Talarmin F . Association of multiple sclerosis and autoimmune thrombopenia. Rev Med Interne 2001;22:1271-1272. Segal JB , Powe NR . Prevalence of english language investigation examples immune thrombocytopenia: analyses of administrative data. The Perfect Christmas A Watch! J Thromb Haemost 2006;4:2377-2383. Munteis E , Segura N , Martinez J , Cuadrado E , Galvez A , Roquer J . English Investigation Examples! Idiopathic thrombocytopenic purpura in patients with multiple sclerosis. Mult Scler 2006;12:S210-S210. Otton SH , Turner DL , Frewin R , Davies SV , Johnson SA . A Watch! Autoimmune thrombocytopenia after treatment with Campath 1H in a patient with chronic lymphocytic leukaemia. Br J Haematol 1999;106:261-262. Haider I , Cahill M . Fatal thrombocytopaenia temporally related to the administration of alemtuzumab (MabCampath) for refractory CLL despite early discontinuation of investigation examples therapy.

Hematology 2004;9:409-411. Loh Y , Oyama Y , Statkute L , et al. Relations! Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of language investigation conditioning regimen used. Of Defamation! Blood 2007;109:2643-2548. Jones JL , Thompson S , Cox AL , Compston DAS , Coles AJ . Neurotrophin production by immune cells after immunotherapy for english language examples, multiple sclerosis. J Neuroimmunol 2004;154:212-212. Paolo Gallo, Diego Centonze, Maria Giovanna Marrosu. . (2017) Alemtuzumab for multiple sclerosis: the new concept of immunomodulation. Multiple Sclerosis and Demyelinating Disorders 2 :1. Maurice Dahdaleh, Raed Alroughani, Mohammed Aljumah, Abdulrahman AlTahan, Issa Alsharoqi, Saeed A Bohlega, Abdulkader Daif, Dirk Deleu, Jihad Inshasi, Rana Karabudak, Mohammed A. How Tall! Sahraian, Karim Taha, Bassem I. Yammout, Magd Zakaria. . (2017) Intervening to reduce the risk of future disability from language, multiple sclerosis: are we there yet?. International Journal of Neuroscience 127 :10, 944-951. Oscar Fernandez. . (2017) Is there a change of paradigm towards more effective treatment early in the course of apparent high-risk MS?.

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Hartung, T. Menge, E. Frohman, B. M. Greenberg, B. What! Hemmer, O. Stuve. . (2014) Requirement for safety monitoring for investigation, approved multiple sclerosis therapies: an overview. Clinical Experimental Immunology 175 :10.1111/cei.2014.175.issue-3, 397-407. P. S. Rommer, A. Dudesek, O. Stuve, U.K. Zettl. . (2014) Monoclonal antibodies in treatment of multiple sclerosis. Clinical Experimental Immunology 175 :10.1111/cei.2014.175.issue-3, 373-384. F. Means! Piehl. . (2014) A changing treatment landscape for multiple sclerosis: challenges and investigation examples, opportunities. Journal of Internal Medicine , n/a-n/a. Alasdair J Coles, Alastair Compston. . (2014) Product licences for Gift: A Watch, alemtuzumab and multiple sclerosis.

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Women and Health, 785-801. Ana de Lorenzo-Pinto, Carmen Guadalupe Rodriguez-Gonzalez, Arantza Ais-Larisgoitia. . (2013) Nuevos tratamientos para la esclerosis multiple. Medicina Clinica 140 , 76-82. Brian C. English Examples! Healy, David Engler, Bonnie Glanz, Alexander Musallam, Tanuja Chitnis. . (2013) Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International 2013 , 1-9. Alireza Minagar. . The Story And Invasion Essay! (2013) Current and Future Therapies for Multiple Sclerosis. Scientifica 2013 , 1-11. Milan Buc. Language Investigation! . (2013) Role of Regulatory T Cells in Pathogenesis and example of defamation, Biological Therapy of Multiple Sclerosis.

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Alastair Wilkins. . (2012) The only carol, way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: No. Multiple Sclerosis Journal 18 :12, 1682-1683. Daniel Ontaneda, Daniela Di Capua. . (2012) Benefits versus risks of latest therapies in english investigation examples multiple sclerosis: a perspective review. Therapeutic Advances in Drug Safety 3 :6, 291-303. Jeffrey A Cohen, Alasdair J Coles, Douglas L Arnold, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Elizabeth Fisher, Vesna V Brinar, Gavin Giovannoni, Miroslav Stojanovic, Bella I Ertik, Stephen L Lake, David H Margolin, Michael A Panzara, D Alastair S Compston. . (2012) Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. The Lancet 380 , 1819-1828. Till Sprenger, Ludwig Kappos. . (2012) Alemtuzumab for multiple sclerosis: who and when to treat?. The Lancet 380 , 1795-1797. Alasdair J Coles, Cary L Twyman, Douglas L Arnold, Jeffrey A Cohen, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Tamara Miller, Elizabeth Fisher, Rupert Sandbrink, Stephen L Lake, David H Margolin, Pedro Oyuela, Michael A Panzara, D Alastair S Compston. How Tall! . Examples! (2012) Alemtuzumab for Christmas Essays, patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial.

The Lancet 380 , 1829-1839. L Midaglia, M Rodriguez Ruiz, D Munoz-Garcia. . English Language Investigation! (2012) Severe haematological complications during treatment with natalizumab. Multiple Sclerosis Journal 18 :11, 1644-1646. Markus Krumbholz, Tobias Derfuss, Reinhard Hohlfeld, Edgar Meinl. . (2012) B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 , 613-623. Alessandro Finkelsztejn, Alberto Alain Gabbai, Yara Dadalti Fragoso, Adriana Carra, Miguel Angel Macias-Islas, Raul Arcega-Revilla, Juan Garcia-Bonitto, Carlos Luis Oehninger-Gatti, Geraldine Orozco-Escobar, Adriana Tarulla, Fernando Vergara, Darwin Vizcarra, , , , , , . . (2012) Latin American algorithm for treatment of relapsing-remitting multiple sclerosis using disease-modifying agents. Arquivos de Neuro-Psiquiatria 70 :10, 799-806. G Ingram, S Hakobyan, CL Hirst, CL Harris, S Loveless, JP Mitchell, TP Pickersgill, NP Robertson, BP Morgan. How Tall Is Dr Jon Lapook! . (2012) Systemic complement profiling in multiple sclerosis as a biomarker of disease state.

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Current Opinion in Neurology 22 , 201-206. Example! Bert A. t Hart, Rogier Q. Hintzen, Jon D. Laman. . (2009) Multiple sclerosis a response-to-damage model. Trends in Molecular Medicine 15 :6, 235-244. Krupa Pandey, Fred D. Lublin. . Examples! (2009) Clinically isolated syndrome and multiple sclerosis: Rethinking the arsenal. Current Treatment Options in Neurology 11 , 193-202. John W. Rose, John F. Foley, Noel G. Carlson. . (2009) Monoclonal antibody treatments for multiple sclerosis. Current Treatment Options in Neurology 11 , 211-220. J Ludovic Croxford, Takashi Yamamura. . (2009) Back to the future for multiple sclerosis therapy: focus on current and emerging disease-modifying therapeutic strategies. Immunotherapy 1 :3, 403-423. Stephen P Cobbold. . Salome! (2009) Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation.

Immunotherapy 1 :3, 447-460. C. Warnke, B.C. Kieseier, U. Zettl, H-P. Hartung. . (2009) Alemtuzumab als neue Therapieoption der Multiplen Sklerose. Der Nervenarzt 80 , 468-474. A. A. Examples! Pace, J. P. Zajicek. . (2009) Melanoma following treatment with alemtuzumab for multiple sclerosis. European Journal of Neurology 16 :10.1111/ene.2009.16.issue-4, e70-e71. The Story And Invasion! Joseph R. Berger, Sidney Houff. . (2009) Opportunistic infections and other risks with newer multiple sclerosis therapies. Language Examples! Annals of Neurology 65 :10.1002/ana.v65:4, 367-377.

(2009) SEP : nouvel ACM, efficace mais toxique. Revue Francophone des Laboratoires 2009 :411, 21. Howard L. Weiner. . (2009) The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?. Annals of neorealism international relations Neurology 65 :10.1002/ana.v65:3, 239-248. Gianluigi Mancardi. . (2009) Further data on autologous haemopoietic stem cell transplantation in multiple sclerosis. The Lancet Neurology 8 , 219-221. Patricia K Coyle. . (2009) Existing therapies for multiple sclerosis offer proven efficacy and safety. Current Opinion in Neurology 22 , S4-S9. Richard K Burt, Yvonne Loh, Bruce Cohen, Dusan Stefosky, Roumen Balabanov, George Katsamakis, Yu Oyama, Eric J Russell, Jessica Stern, Paolo Muraro, John Rose, Alessandro Testori, Jurate Bucha, Borko Jovanovic, Francesca Milanetti, Jan Storek, Julio C Voltarelli, William H Burns. . (2009) Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. The Lancet Neurology 8 , 244-253. Aimee Pasqua Borazanci, Meghan K Harris, Robert N Schwendimann, Eduardo Gonzalez-Toledo, Amir H Maghzi, Masoud Etemadifar, Nadejda Alekseeva, James Pinkston, Roger E Kelley, Alireza Minagar. . (2009) Multiple sclerosis: clinical features, pathophysiology, neuroimaging and future therapies.

Future Neurology 4 :2, 229-246. (2009) Alemtuzumab limits multiple sclerosis but is associated with autoimmune complications. English Investigation Examples! Nature Clinical Practice Neurology 5 , 4-4. Henry F McFarland. . (2009) Alemtuzumab versus interferon beta-1a: implications for pathology and trial design. The Lancet Neurology 8 , 26-28. Randy Osborne. . (2009) Buzz around Campath proof-of-concept trial in MS. Nature Biotechnology 27 , 6-8. Heather J MacLean, Mark S Freedman. . (2009) Multiple sclerosis: following clues from cause to cure. Carol Salome! The Lancet Neurology 8 , 6-8.

Matthew Kaufman, Sewanti A. Limaye, Nancy Driscoll, Christina Johnson, Angelica Caramanica, Yehuda Lebowicz, Dilip Patel, Nina Kohn, Kanti Rai. . (2009) A combination of rituximab, cyclophosphamide and dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia. Leukemia Lymphoma 50 , 892-899. (2008) News in brief. Language Examples! Nature Medicine 14 , 1296-1297. Hauser , Stephen L. , . . (2008) Multiple Lessons for Multiple Sclerosis.

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Feminism/ Theories Of Patriarchy term paper 17703. This is an A grade essay. Assess the claim that gender inequalities in the domestic and occupational divisions of labour are best understood with reference to examples the concept of patriarchy. You should illustrate your answer with reference to a range of feminist perspectives. Western female thought through the centuries has identified the relationship between patriarchy and gender as crucial to The Perfect Christmas Gift: A Watch Essays the womens subordinate position.

For two hundred years, patriarchy precluded women from having a legal or political identity and the legislation and attitudes supporting this provided the model for slavery. English Language Investigation! In the Christmas Gift:, late 19th and english, early 20th centuries suffrage campaigners succeeded in securing some legal and political rights for women in the UK. By the middle of the 20th century, the emphasis had shifted from is dr, suffrage to social and economic equality in the public and private sphere and english, the womens movement that sprung up during the satisfaction means, 1960s began to argue that women were oppressed by patriarchal structures. Equal status for english language examples, women of all races, classes, sexualities and abilities - in ann duffy, the 21st century these feminist claims for english language examples, equality are generally accepted as reasonable principles in western society; yet the contradiction between this principle of equality and the demonstrable inequalities between the sexes that still exist exposes the how tall jon lapook, continuing dominance of male privilege and values throughout society (patriarchy). This essay seeks to move beyond the irrepressible evidence for gender inequality and the division of investigation, labour.

Rather, it poses the question of Gift: A Watch Essays, gender inequality as it manifests itself as an effect of patriarchy drawing from a theoretical body of work which has been developed so recently that it would have been impossible to write this essay thirty years ago. Feminist Theory and Patriarchy. Although patriarchy is arguably the oldest example of a forced or exploitative division of social activities and language investigation, clearly existed before it was ever examined by Gift: Essays, sociologists, the features of patriarchy had been accepted as natural (biological) in substance. It was not until feminists in the 1960s began to explore the features and institutions of patriarchy, that the power of the concept to explain womens subordinate position in society was proven (Seidman, 1994) . The feminist engagement with theories of patriarchy criticised pre-existing theoretical positions and their ideological use, tracing theoretical progenitors of popular views about english language investigation, gender, gender roles etc (Cooper, 1995; Raymond, 1980). Developing theories to explain how gender inequalities have their roots in ideologies of gender difference and a hierarchical gender order, feminist theoretical concepts of The Perfect A Watch Essays, patriarchy are able to explain and english language investigation examples, challenge gender inequality and the gendered division of neorealism international, labour in the private and social spheres (Seidman, 1994). They have done this by challenging concepts of english, gender, the family and the unequal division of The Perfect A Watch, labour underpinned by a theory of language investigation, patriarchy that has come to reveal how it operates to subordinate women and privilege men, often at womens expense. Patriarchy, Structure and Gender Inequality. Walby (1990) reveals how patriarchy operates to achieve and maintain the The Perfect A Watch Essays, gender inequalities essential for the subordination of women. Crucially for this essay, she shows how it can operate differently in the private and public domain but toward the english examples, same end.

She identifies patriarchy as having diverse forms of and relationships between its structures in the public and private spheres, and yet still operates in a related fashion. Walbys explanation sees the household and household production as being a key site of womens subordination but acknowledges that the domestic area is not the only one that women participate in. She shows how the concept of patriarchy is useful in explaining the relationship between womens subordination in of defamation, the private and public arenas by showing that they work equally to achieve this subordination as well as supporting, reflecting and maintaining patriarchy itself. Firstly, Walby points out that the structures of patriarchy differ in their form. The household has a different structure to english investigation other institutional forms, e.g., the workplace. This is an important point because if feminist theories of patriarchy are to international relations stand they must show that patriarchy operates to the same end in both the private and public sphere, even if it uses different strategies, otherwise it could not be the main reason for the continuing inequality of women in english examples, both the private and public sphere.

Walby shows that within the private structure and the public structures, patriarchy does use different strategies to maintain gender inequality and these strategies both achieve the subordination of women. The household strategy is considered to be exclusionary and the public structures strategy as segregationist. The exclusionary strategy in the private arena is relations, based on household production. English Language! Application of example of defamation, this strategy in the domestic sphere depends on individual patriarchs controlling women in the private world of the home. The male patriarch in the household is both the oppressor and recipient of womens subordination. This strategy is direct women are oppressed on a personal and individual basis by the individual patriarchs who share their lives. The segregationist strategy used in the public patriarchy actively excludes women from the public arena using various structures to subordinate them. Language Investigation Examples! Application depends on controlling access to example of defamation public arenas (Golombok and Fivush, 1995).

This strategy does not benefit the institution directly, but it does ensure that individual patriarchs are privileged at the expense of language examples, women, and it maintains gender differences. The way in which individual patriarchs and public institutions use there power further reveals how related the of defamation, structures of patriarchy are. Public institutions do not have the power to oppress individual women or exclude them directly from public structures; this work is carried out in the home. Power in institutions is used collectively rather than individually, and the segregationist strategy pursued in the public arena maintains the exclusionary strategy used in private that in turn supports the segregationist strategy used in public. Yet, the institution can only pursue its segregationist strategy because the individual patriarch subordinates the individual women daily. Walbys description of patriarchal structure looks powerful where there are fewer variables e.g., when women and men seem to share the privilege of being exploited equally as a labour force working equal hours for equal pay in equal conditions (Haug, 1998). Haug (1998) cites research from East Germany which allows her to calculate that women do 4 hours and 41 minutes of domestic labour against mens 2 hours 38 minutes.

Men split their extra two hours between leisure time and paid employment. English Language! She asks if it is a realistic possibility that patriarchy could be so completely and comprehensively asserted in means, as little as two hours a day. Haug does not answer this question (perhaps it is rhetorical) but I think that Walbys (1990) theory of language, patriarchy is international relations, so powerful because it can reveal the answer to questions like this. Walbys theory stands because she shows that the power of patriarchy is asserted in both the private and public sphere simultaneously supporting, reflecting and maintaining itself, regardless of the economic and social framework that prevails. In Haugs case, patriarchy is not being asserted in two hours per examples, day, rather it is an expression of patriarchy, i.e., a symbol of male privilege, which could only be expressed if the general strategies of patriarchal structure were intact and what satisfaction means, functioning. This description of the relationship between patriarchy and structure demonstrates how inequalities in the workplace and in inequality in the home are two sides of the same coin and language investigation, individual males are involved in the direct and indirect subordination of women simultaneously. The concepts that allowed Walby (1990) to define patriarchy as she has are discussed below, with reference to the work of second and third wave feminist thinkers. Gender and Gender Inequalities in the Domestic and Occupational Divisions of Labour. Feminist concepts of gender and gender inequality allow us to refer more or less directly to a theoretical framework for understanding how they have come to form a basis that helps structure the whole of society according to the concept of patriarchy (Seidman, 1994). The gender differences, which lead to gender inequality in the division of labour, and presented as natural by patriarchy and unequal gender order has been normalised and legitimated by science, medicine and popular culture (Raymond, 1980). Example Of Defamation! Feminists hold that this normalisation conceals the social and political formation of an examples, unequal male order, arguing that gender difference is socially produced in order to sustain male dominance (Seidman, 1994).

Frable (1997) points out that there is no basis for a biological account of Essays, gender difference since gender identity can only english language examples refer to the psychological sense of being male or female. Gender is now understood as a social category (Frable, 1997) and so liberal feminism was correct to deny that nature requires rigidly separate and unequal social roles based on gender (Ruehl, 1983). The patriarchal concepts of gender criticised by feminists are used to ascribe the roles that result in gender inequality in the division of relations, labour (Sarup, 1993). This view is supported by Garnsey (1991) when she describes the division of english language, labour as the international relations, differentiation of work tasks organised in structured patterns of english language examples, activity. Carol Ann Duffy! These activities are imposed and remunerated in a specific and unequal manner. When the evidence allows us to place the words according to gender into investigation the last two sentences, and they new sentences mean something, then the concepts of carol salome, patriarchy argued by feminists begin to take on an explanatory power. Occupational Labour and language examples, the Economy.

Liberal feminist provided concepts of gender that account for pay differentials and might even account for why women can receive less money than men for doing the same job (Golombok and Fivush, 1995). They can be used to how tall is dr explain why the political and examples, social change which has allowed substantially greater numbers of women to means enter the labour force has also concentrated them in the poorest employment (Golombok and Fivush, 1995). This is especially so if Garnseys (1991) description of the differentiated and imposed tasks of the division of english language investigation, labour is how tall is dr, used to structure the language investigation examples, argument. However, they do not explain the reasons behind womens oppression and in order to do this Marxist feminists to began to argue that gender inequality has been shaped by capitalist development, highlighting explanations which connect gender inequality with economic needs (e.g., Mitchell J, 1966 used Marxist theory in neorealism international relations, Women: The Longest Revolution). However, while most feminists see the close links between the language examples, organisation of production and the division of labour many thought that there was a limited future for feminism under theories which reduced the specifics of womens lives to the extent that the subjective and interpersonal flavour was not captured (e.g., Firestone S, 1970; The Dialectic of Sex: the Case for of defamation, Feminist Revolution). The socialist or Marxist feminist proposition positions class as the language investigation, most basic form of human conflict but this position was challenged by radical feminists according to does satisfaction means whom, equality does not mean being like men (Sarup, 1993).

Radical feminists successfully argued for the substitution of english investigation examples, gender conflict as the source of all other conflict and fighting for equality in the occupational field became subordinate to challenging the social and cultural order (Sarup, 1993). Asserting that a female identity and subjectivity could only be defined without reference to the patriarchal framework, many radical feminists looked for The Perfect Christmas Gift: A Watch Essays, ways to identify and develop a female culture and way of being which was free from the influences of patriarchy. For example, Irigaray (1985) proposed that this be done through the promotion of entre-femmes, a kind of social form specific to language women. A cultural terrain distinct from womens usual site - the family. Feminist writers have taken the family as a central feature of their explanation of patriarchy but they do not always agree about its role in shaping women to serve patriarchal ends in domesticity and work (Sarup, 1993). Liberal feminism recognized the gendered, social roles of wife and mother but advocated choice for women with respect to marriage, family, career etc., proposing to achieve this through a process of education and reform (Seidman, 1994).

In radical feminism, the neorealism international relations, family is viewed as a major institution whose role is to foster gender inequality through the socialisation of children and subordinate women by forcing them to investigation conform to feminine stereotypes (e.g, Greer G, 1970, The Female Eunuch). Postmodern feminism based on of defamation, Foucaults work explicitly criticises the emphasis on the family as the unit in charge (Sarup, 1993). In order to carry out its functions, the family relies on differential relationships (Broderick, 1993). Coole et al (1990) point out that the functional needs served by the nuclear element of the nuclear family are neither exclusive nor universal which indicates that differentiation it is not essential to the performance of the language investigation, vital functions of the is dr jon lapook, family. This means that the social roles of wife and mother as conceived by liberal feminism are a gendered and manufactured choice. The differential relationships that identify the roles of wife and mother are part of the nuclear family model promoted by patriarchal ideologies for english examples, more than one hundred and fifty years (Coole et al, 1990; p43). This suggests that the example of defamation, one or some of the roles ascribed to the family by other feminists may be more accurate. Despite the differences, feminisms main assertion, that gender identities and roles are socially formed, makes the theoretical proposition that a social and political explanation (patriarchy) can be given for language examples, male dominance and relations, patterns of gender inequality possible (Seidman, 1994). The strength of english language investigation, feminist perspectives on patriarchy is that most of them have been developed from the standpoint of international relations, womens lives (Seidman, 1994) and yet this is also a criticism what womens lives does the standpoint reflect? If feminist perspectives of patriarchy are to language be useful they must not only international make sense structurally, they must also make sense of all womens lives. Lesbian, Black, Third World and post-colonial critics have demonstrated some of the limitations of western feminist agendas that prefer patriarchal accounts of equality to english language investigation examples racialised and cultural accounts (Burman, 1998).

For example, the promotion of reproductive choices by western feminists in the 1970s focussed on contraceptive and abortion rights. However, many women at that time were being discriminated against of defamation because of english language investigation examples, their colour, sexuality or physical abilities and were fighting to keep their children, born and unborn (Burman, 1998). Whilst these criticisms of western feminist raise questions about how and why the priorities of the issues and campaigns these women cho (o)se to think and act on were agreed, they do not suggest an alternative account of inequality in satisfaction means, which the public and private oppression of women is explained (Seidman, 1994). Critics are however right to point out that the feminist account of investigation examples, patriarchy developed by western liberal feminists needs to be expanded to ensure that the experiences of more women can be included but they must also acknowledge that the priorities and concerns of liberal feminists have resulted in some of the most far reaching and carol, important education and legal reforms of this century taking place in the last the last twenty years. These reforms particularly reflect the western feminist concern with differential relationships. In the area of social policy and the law, reformers have begun to language focus on protecting the individual rights of vulnerable household members women, children, and the elderly (MacLean Kurczewzki 1994) at example of defamation the expense of patriarchal privilege. Crucially, whilst the law has become aware of the investigation, potential for the exploitation of family members and in acting underlines the importance of Gift: A Watch, public attitudes and legislation in maintaining gender inequalities and differential relationships; the reform approach cannot be seen as an open acknowledgement that socialisation patterns and family arrangements are male dominated (MacLean Kurczewzki 1994). Following the vote of the General Synod in 1992, the ordination of women in the Church of England has challenged hundreds of years of patriarchal authority and tradition in the church. The implicit relationship between individual men and institutions can be viewed explicitly in the complex provision made to protect those who are individually opposed using the churchs own structures. Regardless of the refusal of key patriarchal institutions to acknowledge the extent to which man have been and are systematically and deliberately privileged by their structures and actions, these dominant forms of power can help produce social change, even if they are only attempting to keep in english language investigation examples, touch with contemporary society (Cooper, 1995).

The process of power is therefore open to change and feminist theorists have shown using their account of patriarchy that the by products of power (e.g., inequality) can be mediated by the institution which represents it and moderated to carol salome be less damaging to individuals (Cooper, 1989). Burman E (ed.) (1998). Deconstructing Feminist Psychology. Sage: London. Broderick CB (1993), Understanding Family Process. Sage: USA. Coole A, Harman H and Hewitt H (1990) Changing Patterns of Family Life, in Eekelaar J and MacLean M (eds.) (1994), A Reader On Family Law, Oxford University Press: England, pp 31:62 (idem. The Family Way, Institute of Public Policy Research, 1990, chap. Language Investigation! 2) Cooper D (1995).

Power in Struggle: Feminism, Sexuality and the State. Open University Press: Buckingham. Frable DES (1997). Gender, Racial, Ethnic, Sexual, and Class Identities. Annual Review of Psychology (48): 139 -162. Garnsey, E (1981). The Rediscovery of the The Story and Invasion of Mars, Divisions of Labour. Theory and Society (10): 337. Graham E, Hinds H, Hobby E and Wilcox H (Eds) (1996). Her Own Life: Autobiographical writings by seventeenth century women (3rd Edition).

Routledge: London. Golombok S and Fivush R (1995). Gender Development. Language Examples! Cambridge University Press: USA. Haug F (1998). Questions Concerning Methods in Feminist Research in Burman E (ed.) (1998). Deconstructing Feminist Psychology (q.v.): 115 139. MacLean M and Kurczewski J (eds.) (1994). Families, Politics, and neorealism international, the Law, Clarendon Press: Oxford. Raymond JG (1980).

The Transsexual Empire. The Womens Press: London. Ruehl S (1983). Sexual Theory and Practice: Another Double Standard. In Cartledge S and Ryan R (1985). Sex and love: New thoughts on Old Contradictions (4th Edition). The Womens Press Limited: London. 210-223. Sarup M (1993). Examples! Post-Structuralism and Postmodernism.

Harvester Wheatsheaf: Hemel Hempstead. Seidman S (1994). How Tall Is Dr! Contested Knowledge: Social Theory in the Postmodern Era (3rd edition). Blackwell: USA. 236-254. Skeggs B (1997). Formations of Class and Gender. Sage: London. Word Count: 2756.

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Essay on Female Genital Mutilation. Circumcision is the removal of the prepuce or the hood of the clitoris. This is the mildest of all type of mutilation (Cutting the Rose). This is the type of mutilation that can be correctly called circumcision, because it would be the english language investigation examples, equivalent to male circumcision (Cutting the Rose). The next type and a little more drastic is excision, which means partial or total cutting of the clitoris and all or part of the labia minor (Cutting the Rose). This is the most widely done of all the circumcision practices. The range of neorealism international relations people getting this type of operation done on english investigation examples them is how tall 80 percent. Infibulation is another type of circumcision. This involves the cutting of the examples, clitoris, labia minora and at least two-thirds of the labia majora (Cutting the Rose).

During this procedure the two sides of the vulva are pinned together by silk or catgut sutures, or thorns. Once this is international relations done there is a small opening that is left so that the female will be able to pass, urine and menstrual blood. The next type of mutilation is Intermediate infibulation. It is called intermediate because it varies on the degrees of english language examples stitching. In one type the clitoris is removed and the surface of the labia minora is roughened to allow stitching. In another situation the example of defamation, clitoris is left intact but the labia minora are removed. In other words the language investigation examples, insides of the labia majoa are removed and stitched with the clitoris buried underneath (Cutting the Rose). With Regard to your recent coverage of female circumcision, while in Malawi a couple of months ago I came across the story of a fourteen year-old girl of the Yao tribe tat inhabits land in The Story and Invasion Essay the southern end of the country. She was diagnosed HIV-positive although she was a virgin. Blame was laid on the fact that during tribal circumcision the same razor would be used on investigation examples any number of children at the same time.

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Since students attending schools located in poor areas tend to score lower, distributing funds thi way is the equivalent of deliberately denying financial aid to those schools that most need it. Furthermore, since much of the student body in these schools consists of minorities, this unfair distribution policy is, essentially, discrimination. Since schools rely upon state grants to cover many of their expenses, when they receive less money, students suffer. Thus, educators who teach in poor areas are further pressured to provide a superficial education, covering only areas which are tested, so that the english language investigation, school will receive more funding. On this topic, Alfie Kohn, a former educator and opponent of standardized testing, states that.

those who teach low-scoring populations will. be most likely to be branded as failures. Of Defamation! If. excellent teachers and principals decide to. leave the profession as a result of incessant. pressure to raise scores, we would expect. minority and english investigation low-income students to be. disproportionately affected by the departure of. these educators. Jon Lapook! (Poor Teaching) Standardized testing, as the most abundant method of language examples evaluation, is grossly flawed. A study that was published in the Journal of Educational Psychology stated that students who think superficially, that is, those who guess at or copy answers and skip harder parts, tend to score higher on standardized tests than those who ask questions and try to connect present lessons with previous ones.

These tests are measuring and rewarding superficial thinking more than active thinking. Moreover, tests such as the CAT, MAT, and SAT were not designed to measure teaching or learning. They were designed in such a way that only one half of students would answer correctly, resulting in a wide range of scores. A Watch Essays! Kohn asserts that The main objective of these tests is to rank, not to rate; to english language examples spread out the scores, not to gauge the quality of a given student or school (Standardized Testing). this issue. The reasons for the concern on behalf. of the federal government are astounding. Of Mars! This. policy states, Research has shown that English. language learners, when compared to their English- fluent peers, tend to receive lower grades and.

often score below the average on standardized. math and reading assessments. First of all, it. is incredible that this finding comes as a surprise to anyone. If we sent American.